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Titolo:
HUMAN NAIVE CD4 T-CELLS PRODUCE INTERLEUKIN-4 AT PRIMING AND ACQUIRE A TH2 PHENOTYPE UPON REPETITIVE STIMULATIONS IN NEUTRAL CONDITIONS
Autore:
DEMEURE CE; YANG LP; BYUN DG; ISHIHARA H; VEZZIO N; DELESPESSE G;
Indirizzi:
UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB,M4211-K MONTREAL PQ H2L 4M1 CANADA UNIV MONTREAL,NOTRE DAME HOSP,LOUIS CHARLES SIMARD RES CTR,ALLERGY RES LAB MONTREAL PQ H2L 4M1 CANADA
Titolo Testata:
European Journal of Immunology
fascicolo: 9, volume: 25, anno: 1995,
pagine: 2722 - 2725
SICI:
0014-2980(1995)25:9<2722:HNCTPI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LYMPHOCYTES; IL-4; LYMPHOKINES; ANTIBODIES; EXPRESSION; INVITRO; MEMORY;
Keywords:
INTERLEUKIN-4; T CELL MATURATION; HUMAN TH2 CELLS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.E. Demeure et al., "HUMAN NAIVE CD4 T-CELLS PRODUCE INTERLEUKIN-4 AT PRIMING AND ACQUIRE A TH2 PHENOTYPE UPON REPETITIVE STIMULATIONS IN NEUTRAL CONDITIONS", European Journal of Immunology, 25(9), 1995, pp. 2722-2725

Abstract

The maturation of naive CD4 T cells into interleukin (IL)-4-producingeffecters was shown to require the presence of IL-4 at priming, the cellular origin of which remains unclear. We demonstrate here that naive T cells themselves release IL-4 at very low levels that are nevertheless sufficient to promote their development into Th2-like cells. Thisconclusion is based on three observations: (1) highly purified human naive CD4 T cells, of neonatal or adult origin, develop into Th2 effecters upon repetitive cycles of stimulation with anti-CD3 monoclonal antibody (mAb) cross-linked to CD32-B7 transfected L fibroblasts followed by IL-2 expansion; (2) IL-4 protein is readily detectable in the concentrated supernatant fluids of priming cultures performed in the presence of anti-IL-4 receptor mAb; and (3) addition of anti-IL-4 or anti-IL-dr receptor mAb at priming markedly inhibits the acquisition of IL-4- and IL-5-producing capacity while enhancing that of interferon-gamma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 04:48:35