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Titolo:
EFFECT OF EXPERIMENTAL RHINOVIRUS 16 COLDS ON AIRWAY HYPERRESPONSIVENESS TO HISTAMINE AND INTERLEUKIN-8 IN NASAL LAVAGE IN ASTHMATIC SUBJECTS IN-VIVO
Autore:
GRUNBERG K; TIMMERS MC; SMITS HH; DEKLERK EPA; DICK EC; SPAAN WJM; HIEMSTRA PS; STERK PJ;
Indirizzi:
LEIDEN UNIV,MED CTR,DEPT PULMONOL,POB 9600 NL-2300 RC LEIDEN NETHERLANDS LEIDEN UNIV,MED CTR,DEPT VIROL NL-2300 RC LEIDEN NETHERLANDS UNIV WISCONSIN,DEPT PREVENT MED MADISON WI 00000
Titolo Testata:
Clinical and experimental allergy
fascicolo: 1, volume: 27, anno: 1997,
pagine: 36 - 45
SICI:
0954-7894(1997)27:1<36:EOER1C>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CC-CHEMOKINES; INFECTION; EXACERBATIONS; INFLAMMATION; CHILDREN; ADULTS; SECRETIONS; VIRUSES; PRECIPITANTS; INHALATION;
Keywords:
ASTHMA; ASTHMA EXACERBATION; COMMON COLD; RHINOVIRUS; AIRWAY HYPERRESPONSIVENESS; INTERLEUKIN-8; NASAL LAVAGE; CHEMOKINES; LYMPHOCYTES; NEUTROPHILS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
K. Grunberg et al., "EFFECT OF EXPERIMENTAL RHINOVIRUS 16 COLDS ON AIRWAY HYPERRESPONSIVENESS TO HISTAMINE AND INTERLEUKIN-8 IN NASAL LAVAGE IN ASTHMATIC SUBJECTS IN-VIVO", Clinical and experimental allergy, 27(1), 1997, pp. 36-45

Abstract

Background Asthma exacerbations are closely associated with respiratory virus infections. However, the pathophysiological consequences of such infections in asthma are largely unclear. Objective To examine theeffect of rhinovirus 16 (RV16) infection on airway hypersensitivity to histamine, and on interleukin-8 (IL-8) in nasal lavage. Methods Twenty-seven non-smoking atopic, mildly asthmatic subjects participated ina placebo-controlled, parallel study. A dose of 0.5-2.9 x 10(4) TCID50 RV16 or placebo was nasally administered. Cold symptoms were recorded by questionnaire throughout the study. Histamine challenges were performed at entry, and on days 4 and 11 after inoculation. Nasal lavageswere obtained at entry, and on days 2 and 9. The response to histamine was measured by PC20 (changes expressed as doubling doses: DD). IL-8levels were obtained by ELISA, and were expressed in ng/ml. Results RV infection was confirmed by culture of nasal lavage and/or by antibody titre rise in each of the RV16-treated subjects. Among the 19 RV16-treated subjects, eight developed severe cold symptoms. Baseline FEV(1)did not change significantly during the study in either treatment group (P = 0.99). However, in the RV16-treated subjects there was a decrease in PC20 at day 4, which was most pronounced in those with a severecold (mean change +/- SEM: -1.14 +/- 0.28 DD, P = 0.01). In addition,IL-8 levels increased in the RV16 group at days 2 and 9 (P < 0.001). The increase in nasal IL-8 at day 2 correlated significantly with the change in PC20 at day 4 (r = -0.48, P = 0.04). Conclusion We conclude that the severity of cold, as induced by experimental RV16 infection, is a determinant of the increase in airway hypersensitivity to histamine in patients with asthma. Our results suggest that this may be mediated by an inflammatory mechanism, involving the release of chemokines such as IL-8.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:58:47