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Titolo:
RAT DUODENUM NITRERGIC-INDUCED RELAXATIONS ARE, CGMP-INDEPENDENT AND APAMIN-SENSITIVE
Autore:
MARTINS SLR; DEOLIVEIRA RB; BALLEJO G;
Indirizzi:
UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL,AVE BANDEIRANTES 3900 BR-14049900 RIBEIRAO PRET BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT CLIN MED BR-05508 SAO PAULO BRAZIL UNIV SAO PAULO,FAC MED RIBEIRAO PRETO,DEPT FARMACOL BR-05508 SAO PAULO BRAZIL
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 284, anno: 1995,
pagine: 265 - 270
SICI:
0014-2999(1995)284:3<265:RDNRAC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER ESOPHAGEAL SPHINCTER; INHIBITORY JUNCTION POTENTIALS; CYCLIC-NUCLEOTIDE CONTENT; GUINEA-PIG ILEUM; NITRIC-OXIDE; GUANYLATE-CYCLASE; SODIUM-NITROPRUSSIDE; SMOOTH-MUSCLE; GMP; ACTIVATION;
Keywords:
PROXIMAL DUODENUM, RAT; NITRIC OXIDE (NO); NANC (NONADRENERGIC, NONCHOLINERGIC) NERVE; SMOOTH MUSCLE RELAXATION; APAMIN; K+ CHANNEL; CGMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
S.L.R. Martins et al., "RAT DUODENUM NITRERGIC-INDUCED RELAXATIONS ARE, CGMP-INDEPENDENT AND APAMIN-SENSITIVE", European journal of pharmacology, 284(3), 1995, pp. 265-270

Abstract

The effects of the K+ channel blockers, apamin, tetraethylammonium and 4-aminopyridine, upon the relaxations of the isolated rat proximal duodenum induced by nitrergic nerve ac tivation, nitric oxide (NO), theNO donor 3-morpholinosydnonimine (SIN-1) and Br-cyclic GMP were determined. The effects of the guanylate cyclase inhibitors, cystamine and N-methylhydroxylamine, on NO-, SIN-1- and nitrergic nerve-induced responses were also investigated. Apamin inhibited nitrergic nerve-, NO-and SIN-1-induced relaxations but did not affect those induced by Br-cGMP. Tetraethylammonium and 4-aminopyridine as well as cystamine and N-methylhydroxylamine failed to affect the relaxations caused by any of the agents tested. These findings indicate that, in the rat proximal duodenum, nitrergic nerve activation as well as exogenous nitric oxide cause relaxation through a cGMP-independent, apamin sensitive mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 12:13:23