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Titolo:
QUANTITATIVE DIFFERENCES IN NEOGLYCOPROTEIN BINDING FOR VASCULAR ENDOTHELIAL-CELLS FROM PORCINE BRAIN, OVARY, AND TESTIS IN-VITRO
Autore:
PLENDL J; SINOWATZ F; AUERBACH R; GABIUS HJ;
Indirizzi:
UNIV MUNICH,FAC VET MED,INST VET MED,VET STR 13 D-80539 MUNICH GERMANY UNIV WISCONSIN,CTR DEV BIOL MADISON WI 53706 UNIV MUNICH,FAC VET MED,INST PHYSIOL CHEM D-80539 MUNICH GERMANY
Titolo Testata:
Microvascular research
fascicolo: 2, volume: 50, anno: 1995,
pagine: 199 - 214
SICI:
0026-2862(1995)50:2<199:QDINBF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARIN ENDOGENOUS LECTINS; BIOTINYLATED NEOGLYCOPROTEINS; CEREBELLAR ONTOGENY; ADHESION MOLECULES; MEMBRANE LECTINS; ORGAN PREFERENCE; SUGAR RECEPTORS; EXPRESSION; HETEROGENEITY; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
J. Plendl et al., "QUANTITATIVE DIFFERENCES IN NEOGLYCOPROTEIN BINDING FOR VASCULAR ENDOTHELIAL-CELLS FROM PORCINE BRAIN, OVARY, AND TESTIS IN-VITRO", Microvascular research, 50(2), 1995, pp. 199-214

Abstract

Carrier-immobilized carbohydrates are valuable tools for assessing the glycoligand-binding capacity of cell surfaces. A panel of 10 types of fluorescent neoglycoproteins has been synthesized to determine the extent of their specific binding to endothelial cells in vitro that have been obtained from porcine brain, ovary, and testis. Different sugarmoieties revealed a nonuniform capacity to bind to the endothelial cells as determined by flow cytometric analysis, the histogenetic originof the preparations being an important factor. Binding of mannose, xylose, and glucuronic acid was especially pronounced, but the extent ofcell-associated fluorescence was significantly different dependent onthe source of the endothelial cells. These results clearly reveal that endothelial cells in vitro display the capacity to specifically recognize defined carbohydrate moieties. Moreover, endothelial cells of different tissue origin can exhibit variability in this property, potentially endowing this cell type with site-dependent molecular properties. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:21:06