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Titolo:
INTRATHYMICALLY EXPRESSED C-KIT LIGAND (STEM-CELL FACTOR) IS A MAJOR FACTOR DRIVING EXPANSION OF VERY IMMATURE THYMOCYTES IN-VIVO
Autore:
RODEWALD HR; KRETZSCHMAR K; SWAT W; TAKEDA S;
Indirizzi:
BASEL INST IMMUNOL,GRENZACHERSTR 487 CH-4005 BASEL SWITZERLAND
Titolo Testata:
Immunity
fascicolo: 3, volume: 3, anno: 1995,
pagine: 313 - 319
SICI:
1074-7613(1995)3:3<313:IECL(F>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE RECEPTOR; GROWTH-FACTOR; W-LOCUS; THYMUS DEVELOPMENT; PRECURSOR CELLS; TRANSGENIC MICE; PROTO-ONCOGENE; GENE-PRODUCT; MOUSE THYMUS; SI-LOCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
H.R. Rodewald et al., "INTRATHYMICALLY EXPRESSED C-KIT LIGAND (STEM-CELL FACTOR) IS A MAJOR FACTOR DRIVING EXPANSION OF VERY IMMATURE THYMOCYTES IN-VIVO", Immunity, 3(3), 1995, pp. 313-319

Abstract

To investigate the role of the receptor-type tyrosine kinase, c-kit and its ligand, stem cell factor (SCF) in T cell development, we analyzed c-kit (W/M) and SCF (SCF) deficient mice. We also engrafted wild-type or SCF-deficient fetal thymi onto wild-type recipient mice and analyzed the rate of proliferation by in vivo bromodeoxyuridine labeling. The results show that the most immature thymocyte compartment defined as CD3(-)CD4(-)CD8(-) is significantly reduced in SI/SI grafts and W/Wthymi compared with wild-type counterparts. Also, the expansion rate of these immature thymocytes in SI/SI graft is reduced by similar to 50%. These experiments provide direct evidence for an important role for c-kit-SCF interactions in expansion of very early thymocytes.

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Documento generato il 27/11/20 alle ore 04:41:19