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Titolo:
DOES SLEEP ENHANCE THE EFFECT OF SUBANESTHETIC ISOFLURANE ON HYPOXIC VENTILATION
Autore:
FOO IT; MARTIN SE; FRIED MJ; DOUGLAS NJ; DRUMMOND GB; WARREN PM;
Indirizzi:
ROYAL EDINBURGH INFIRM,DEPT ANAESTHET,LAUISTON PL EDINBURGH EH3 9YW MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT ANAESTHESIA EDINBURGH MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT MED,RESP MED UNIT EDINBURGH MIDLOTHIAN SCOTLAND
Titolo Testata:
Anesthesia and analgesia
fascicolo: 4, volume: 81, anno: 1995,
pagine: 751 - 756
SICI:
0003-2999(1995)81:4<751:DSETEO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINED HYPOXIA; NORMAL ADULTS; HUMANS; DEPRESSION; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
I.T. Foo et al., "DOES SLEEP ENHANCE THE EFFECT OF SUBANESTHETIC ISOFLURANE ON HYPOXIC VENTILATION", Anesthesia and analgesia, 81(4), 1995, pp. 751-756

Abstract

After surgery, patients may receive little audiovisual stimulation and may sleep. Lack of audiovisual stimulation enhances the suppression of the hypoxic ventilatory response (HVR) by 0.1 minimum alveolar anesthetic concentration (MAC) isoflurane. Sleep also reduces the HVR and may thus increase the risk of hypoxia in patients at this time. We therefore measured the ventilatory response in volunteers to a sustained step hypoxic stimulus (mean arterial oxygen saturation [SaO(2)] 80% [SEM 0.3] for 20 min) in the presence of 0.1 MAC isoflurane, with subjects in the awake and asleep states. The behavioral states were studied in random order in nine male subjects. The combination of isoflurane and sleep significantly reduced (P < 0.05) normoxic ventilation (6.71 [0.39] vs 8.24 [0.29] L/min) and increased end-tidal PCO2 (PETCO(2)) (43.1 [0.5] vs 40.4 [0.8] mm Hg) compared with the awake state. However,ventilation was similar in the asleep and awake states during early (15.10 [1.35] vs 15.50 [1.61] L/min) and late (10.45 [0.97] vs 11.03 [0.39] L/min) hypoxia in the presence of isoflurane. Thus sleep did not reduce ventilation during hypoxia in the presence of isoflurane sedation. The increase in PETCO(2) during sleep may have offset suppression of the HVR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:19:46