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Titolo:
BLOOD-COAGULATION EQUILIBRIUM IN RAT-LIVER MICROCIRCULATION AS EVALUATED BY ENDOTHELIAL-CELL THROMBOMODULIN AND MACROPHAGE TISSUE FACTOR
Autore:
ARAI M; MOCHIDA S; OHNO A; OGATA I; OBAMA H; MARUYAMA I; FUJIWARA K;
Indirizzi:
SAITAMA MED SCH,DEPT INTERNAL MED 3,38 MOROHONGO MOROYAMA SAITAMA 35004 JAPAN SAITAMA MED SCH,DEPT INTERNAL MED 3 MOROYAMA SAITAMA 35004 JAPAN UNIV TOKYO,FAC MED,DEPT INTERNAL MED 1,BUNKYO KU TOKYO 113 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 3 KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT CLIN MED KAGOSHIMA 890 JAPAN
Titolo Testata:
Thrombosis research
fascicolo: 2, volume: 80, anno: 1995,
pagine: 113 - 123
SICI:
0049-3848(1995)80:2<113:BEIRMA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MASSIVE HEPATIC-NECROSIS; INTRAVASCULAR COAGULATION; CORYNEBACTERIUM-PARVUM; PROCOAGULANT ACTIVITY; INSITU EVALUATION; ENDOTOXIN; FAILURE;
Keywords:
THROMBOMODULIN; TISSUE FACTOR; SINUSOIDAL ENDOTHELIAL CELL; TISSUE FACTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
M. Arai et al., "BLOOD-COAGULATION EQUILIBRIUM IN RAT-LIVER MICROCIRCULATION AS EVALUATED BY ENDOTHELIAL-CELL THROMBOMODULIN AND MACROPHAGE TISSUE FACTOR", Thrombosis research, 80(2), 1995, pp. 113-123

Abstract

The regulatory mechanisms of microcirculation might differ in the liver from other organs, because macrophages are resident in the hepatic sinusoids and sinusoidal endothelial cells are unique in shape and function. Thrombomodulin expression in endothelial cells and tissue factor activity in isolated macrophages were studied in the liver acid lungof rats. In normal rats, the thrombomodulin expression was minimal inhepatic sinusoids, but prominent in pulmonary capillaries, while the tissue factor activity in the presence of endotoxin was higher in pulmonary macrophages than in Kupffer cells, although the levels in the absence of endotoxin were comparable in both cells. The tissue factor activity in hepatic macrophages was increased after priming of the cellswith Corynebacterium parvum or after induction of liver necrosis or cirrhosis with carbon tetrachloride. In the necrotic or cirrhotic liver, increased thrombomodulin expression was seen along capillaries extending in necrotic areas and regenerating nodules, but this increase wasminimal in the Corynebacterium parvum-treated rat liver. Blood coagulation equilibrium in microcirculation regulated by endothelial cells and macrophages may differ between the liver and lung. Such equilibriumin the liver may vary depending on pathological status.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 09:22:21