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Titolo:
CLINICAL, BIOLOGICAL, AND IMMUNOPHENOTYPICAL CHARACTERISTICS OF B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA WITH TRISOMY-12 BY FLUORESCENCE IN-SITUHYBRIDIZATION
Autore:
TABERNERO MD; SANMIGUEL JF; GARCIA JL; GARCIAISIDORO M; WIEGANT J; CIUDAD J; GONZALEZ M; RIOS A; RAAP A; ORFAO A;
Indirizzi:
HOSP UNIV SALAMANCA,HEMATOL LAB,SERV GEN CITOMETRIA,PASEO SAN VICENTES-N E-37007 SALAMANCA SPAIN UNIV SALAMANCA,CYTOMETRY UNIT E-37008 SALAMANCA SPAIN UNIV SALAMANCA,DEPT HAEMATOL E-37008 SALAMANCA SPAIN LEIDEN UNIV,SYLVIUS LAB LEIDEN NETHERLANDS
Titolo Testata:
Cytometry
fascicolo: 3, volume: 22, anno: 1995,
pagine: 217 - 222
SICI:
0196-4763(1995)22:3<217:CBAICO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONRADIOACTIVE INSITU HYBRIDIZATION; CHROMOSOME-ABNORMALITIES; PROLYMPHOCYTIC LEUKEMIA; PROGNOSTIC-SIGNIFICANCE; CYTOGENETIC ANALYSIS; LYMPHOID LEUKEMIAS; FEATURES; SURVIVAL; STAGE; DNA;
Keywords:
B-CLL; TRISOMY 12; FISH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Tabernero et al., "CLINICAL, BIOLOGICAL, AND IMMUNOPHENOTYPICAL CHARACTERISTICS OF B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA WITH TRISOMY-12 BY FLUORESCENCE IN-SITUHYBRIDIZATION", Cytometry, 22(3), 1995, pp. 217-222

Abstract

The clinical, biological, and immunophenotypical characteristics of B-cell chronic lymphocytic leukemia (B-CLL) patients with trisomy 12 detected by fluorescence in situ hybridization (FISH) using a chromosome12 alpha-centromeric probe (D12Z3) were analyzed in the present study. From a total of 104 consecutive B-CLL patients, 21 (20%) displayed trisomy 12, the percentage of trisomic cells ranging from 13% to 76%. From the clinico-biological point of view, patients with trisomy 12 were associated with atypical CLL morphology (43% vs. 10%, P = 0.04) and BM diffuse pattern (75% vs. 25%, P = 0.02) together with increased WBCcounts (141 +/- 220 vs. 58 +/- 67 x 10(9)/L, P = 0.04). In contrast, no association was detected between the presence of trisomy 12 and other disease characteristics such as age, sex, clinical stage, hepatomegaly, lymphadenopathies, haemoglobin levels and platelet counts, and the cell cycle distribution of PB leukocytes in both groups of patients. Trisomy 12 patients had a significantly higher expression of the FMC7antigen both in percentage (34 +/- 34% vs. 13 +/- 20%, P = 0.02) and absolute numbers (29 +/- 62 vs. 7 +/- 17 x 10(9)/L, P = 0.007). No major differences were found regarding the expression of mouse rosettes, CD19+, and CD19+/CD5+ lymphocytes. Upon analyzing the correlations between the disease characteristics of trisomy 12 cases, significant associations were found between the percentage of trisomic cells and both the WBC count (r = 0.52, P = 0.02) and the PB lymphocyte count (r = 0.60, P = 0.007). In summary, our results show that although trisomy 12 in B-CLL is not associated with the clinical stage, it correlates withseveral prognostic factors and other disease characteristics such as an atypical lymphocyte morphology, BM diffuse pattern, high WBC counts, and FMC7 expression. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 23:59:11