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Titolo:
A NEW AND SENSITIVE TOOL FOR AUTONOMIC DYSFUNCTION - ANALYSIS BY RADIOLABELED METAIODOBENZYLGUANIDINE (MIBG) IN PATIENTS WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY (FAP)
Autore:
ANDO Y; OBAYASHI K; TANAKA Y; YAMASHITA T; UCHINO M; ANDO M;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DEPT INTERNAL MED 1,1-1-1 HONJO KUMAMOTO 860 JAPAN
Titolo Testata:
AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION
fascicolo: 3, volume: 2, anno: 1995,
pagine: 183 - 187
SICI:
1350-6129(1995)2:3<183:ANASTF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; METAIODOBENZYLGUANIDINE; LOCALIZATION;
Keywords:
MIBG; R-R INTERVAL; AUTONOMIC DYSFUNCTION; FAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ando et al., "A NEW AND SENSITIVE TOOL FOR AUTONOMIC DYSFUNCTION - ANALYSIS BY RADIOLABELED METAIODOBENZYLGUANIDINE (MIBG) IN PATIENTS WITH FAMILIAL AMYLOIDOTIC POLYNEUROPATHY (FAP)", AMYLOID-INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION, 2(3), 1995, pp. 183-187

Abstract

I-123-MIBG (5 mCi) scintigraphy was applied and compared with power spectrum and coefficient of variance (CV) of the electrocardiographic R-R interval in 9 patients with familial amyloidotic polyneuropathy (FAP). Although a significant decrease of MIBG uptake was seen in all thepatients examined, no change in either the ST or T wave in the electrocardiogram (ECG) nor any ultrasound echocardiography (UCG) abnormalities were recognized. Six of these patients under (201)thallium (Tl-201) scintigraphy exhibited a normal pattern. The electrocardiographic R-R interval, was border-line in one patient and could not be calculatedin 3 patients. In contrast, total absence of I-123-MIBG accumulation was recognized in 6 patients and in 3, a partial defect was found. These results suggest that MIBG scintigraphy may be a useful method for the diagnosis of dysautonomia in patients with FAP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:46:43