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Titolo:
NONSTEROIDAL ANTIINFLAMMATORY DRUG-INDUCED GASTRODUODENAL INJURY IN CHILDREN
Autore:
DOWD JE; CIMAZ R; FINK CW;
Indirizzi:
5085 W BRISTOL FLINT MI 48507 UNIV TEXAS,SW MED CTR DALLAS TX 00000 TEXAS SCOTTISH RITE HOSP CHILDREN DALLAS TX 75219
Titolo Testata:
Arthritis and rheumatism
fascicolo: 9, volume: 38, anno: 1995,
pagine: 1225 - 1231
SICI:
0004-3591(1995)38:9<1225:NADGII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE RHEUMATOID-ARTHRITIS; PEPTIC-ULCER DISEASE; UPPER GASTROINTESTINAL-DISEASE; ANTI-INFLAMMATORY DRUGS; SEGMENT-I; GASTROPATHY; ASSOCIATION; ASPIRIN; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Dowd et al., "NONSTEROIDAL ANTIINFLAMMATORY DRUG-INDUCED GASTRODUODENAL INJURY IN CHILDREN", Arthritis and rheumatism, 38(9), 1995, pp. 1225-1231

Abstract

Objective, To determine the incidence of abdominal pain and gastroduodenal injury in children with arthritis taking nonsteroidal antiinflammatory drugs (NSAIDs). Methods, A retrospective review of the records of all children (570 patients) receiving followup care in an academic rheumatology clinic between 1991 and 1993 was performed. Results, There were 344 patients who used NSAIDs during the study period, Abdominalpain was recorded in 27.9% of patients taking NSAIDs and 14.6% of patients not taking NSAIDs, Abdominal pain in 47 patients (49%) taking NSAIDs and 14 patients (42%) not taking NSAIDs was evaluated radiographically and/or endoscopically, Among those patients evaluated, gastric or duodenal injury was found in 16 (34.0%) who were taking NSAIDs and 1(7.1%) who were not, This represented a relative risk for gastroduodenal injury of 4.8 for patients taking NSAIDs (P = 0.09). The incidenceof injury did not change when analyses were controlled for prednisoneor slow-acting antirheumatic drug use, None of the children were hospitalized or died as a result of gastroduodenal injury during the 3-year period. Conclusion. We conclude that NSAID use in children with arthritis frequently leads to gastroduodenal injury, with an estimated incidence and relative risk that are comparable to the rates found in adults with arthritis taking NSAIDs, but that hospitalization or death asa result of this injury is uncommon.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 03:17:06