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Titolo:
EXPLORATION OF SIMPLE INSULIN SENSITIVITY MEASURES DERIVED FROM FREQUENTLY SAMPLED INTRAVENOUS GLUCOSE-TOLERANCE (FSIGT) TESTS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY
Autore:
ANDERSON RL; HAMMAN RF; SAVAGE PJ; SAAD MF; LAWS A; KADES WW; SANDS RE; CEFALU W;
Indirizzi:
QUINTILES INC,POB 13979 RES TRIANGLE PK NC 27709 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT INTERNAL MED WINSTON SALEM NC 27103 UNIV COLORADO,HLTH SCI CTR,DEPT PREVENT MED & BIOMETR DENVER CO 80262 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 UNIV SO CALIF,SCH MED,DEPT MED LOS ANGELES CA 90033 STANFORD UNIV,SCH MED,DEPT MED PALO ALTO CA 94304
Titolo Testata:
American journal of epidemiology
fascicolo: 7, volume: 142, anno: 1995,
pagine: 724 - 732
SICI:
0002-9262(1995)142:7<724:EOSISM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINIMAL MODEL; CLAMP; INDEX;
Keywords:
GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; INSULIN; INSULIN RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R.L. Anderson et al., "EXPLORATION OF SIMPLE INSULIN SENSITIVITY MEASURES DERIVED FROM FREQUENTLY SAMPLED INTRAVENOUS GLUCOSE-TOLERANCE (FSIGT) TESTS - THE INSULIN-RESISTANCE ATHEROSCLEROSIS STUDY", American journal of epidemiology, 142(7), 1995, pp. 724-732

Abstract

Both abnormal insulin levels and low insulin sensitivity have been implicated as risk factors for Type II diabetes mellitus and cardiovascular disease. While insulin level is relatively simple to assess, direct measurement of insulin sensitivity is much more invasive, costly, and time-consuming, The authors considered eight previously described measures or indices of insulin sensitivity derived from the frequently sampled intravenous glucose tolerance test (FSIGT). Each one was evaluated by strength and consistency of association with insulin sensitivity computed from glucose clamp (S-l(clamp), across three glucose tolerance groups, including participants with normal glucose tolerance (n = 11), impaired glucose tolerance (n = 20), and non-insulin-dependent diabetes mellitus (n = 24). Minimal model analysis (MINMOD S-l(22), based on the 22-sample FSIGT, performed best based on statistical criteriaof strong and consistent association with S-l(clamp) . An insulin sensitivity measure similar to that of Galvin et al. (Diabetic Medicine 1990;9:921-8), defined as glucose disappearance (10-50 minutes) dividedby insulin area under the curve above baseline from 0-50 minutes, performed best based on statistical criteria and time-savings. Galvin insulin sensitivity is simple to calculate, requires only a 50-minute FSIGT, and is significantly (p < 0.001) and not inconsistently (p = 0.12 for inconsistent association) associated with S-l(clamp) over a wide range of glucose tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:10:56