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Titolo:
SENSITIVITY AND SPECIFICITY OF A NEW ELISA METHOD FOR DETERMINATION OF CHROMOGRANIN-A IN THE DIAGNOSIS OF PHEOCHROMOCYTOMA AND NEUROBLASTOMA
Autore:
BOOMSMA F; BHAGGOE UM; TVELD AJMI; SCHALEKAMP MADH;
Indirizzi:
UNIV HOSP DIJKZIGT,DEPT INTERNAL MED 1,COEUR,CARDIOVASC RES INST,DR MOLEWATERPL 40 3015 GD ROTTERDAM NETHERLANDS
Titolo Testata:
Clinica chimica acta
fascicolo: 1, volume: 239, anno: 1995,
pagine: 57 - 63
SICI:
0009-8981(1995)239:1<57:SASOAN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOIMMUNOASSAY; STORAGE; SERUM; SECRETION;
Keywords:
CHROMOGRANIN A; ELISA; PHEOCHROMOCYTOMA; NEUROBLASTOMA; HYPERTENSION; KIDNEY FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
F. Boomsma et al., "SENSITIVITY AND SPECIFICITY OF A NEW ELISA METHOD FOR DETERMINATION OF CHROMOGRANIN-A IN THE DIAGNOSIS OF PHEOCHROMOCYTOMA AND NEUROBLASTOMA", Clinica chimica acta, 239(1), 1995, pp. 57-63

Abstract

We have evaluated a new commercially available ELISA kit for determination of plasma chromogranin A with respect to its usefulness in the diagnosis of neuroendocrine tumors, mainly pheochromocytoma. Serum and differently anticoagulated plasmas gave different chromogranin A concentrations. Control values (n = 21) were 18.9 +/- 5.8 units/l. Chromogranin A values > 30.4 units/l (mean + 2 S.D.) were considered elevated. In 22 patients suspected of(but found not to have) pheochromocytoma and in 24 patients with renovascular hypertension, 18% were found to have elevated chromogranin A concentrations. In renovascular hypertension chromogranin A correlated positively with serum creatinine; chromogranin A was strongly elevated especially in chronic renal failure. In 45 patients with pheochromocytoma, 13 (29%) had chromogranin A concentrations within the normal range, as had 3 out of 11 patients with neuroblastoma (27%). In 13 pheochromocytoma patients with elevated chromogranin A, measurements were repeated after surgical removal of the tumor; values then all fell within the normal range. We conclude that measurement of chromogranin A adds little to already existing methods for the diagnosis of pheochromocytoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:01:48