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Titolo:
SERUM-LIPIDS IN SUICIDE ATTEMPTERS
Autore:
ENGSTROM G; ALSEN M; REGNELL G; TRASKMANBENDZ L;
Indirizzi:
UNIV LUND HOSP,DEPT PSYCHIAT,LUND SUICIDE RES CTR S-22185 LUND SWEDEN
Titolo Testata:
Suicide & life-threatening behavior
fascicolo: 3, volume: 25, anno: 1995,
pagine: 393 - 400
SICI:
0363-0234(1995)25:3<393:SISA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWERING CHOLESTEROL CONCENTRATIONS; DENSITY-LIPOPROTEIN CHOLESTEROL; PANIC DISORDER; MONOAMINE METABOLITES; MORTALITY; BEHAVIOR; PLASMA; HOPELESSNESS; FAT; MEN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Engstrom et al., "SERUM-LIPIDS IN SUICIDE ATTEMPTERS", Suicide & life-threatening behavior, 25(3), 1995, pp. 393-400

Abstract

As other studies have shown possible associations of low serum cholesterol concentrations as well as serotonin and corticosteroid devianceswith suicide or depression, the present study was undertaken to investigate the serum lipid levels in subgroups of suicide attempters. Serum lipids were determined in 72 suicide attempters. Cerebrospinal fluidmonoamine metabolites and plasma cortisol levels were measured, and dexamethasone suppression tests were performed. Hopelessness and suicidality were rated by the Hopelessness Scale (HS) and the Suicidal Intent Scales (SIS). The mean total serum cholesterol (TSC) level was 5.0 +/- 1.2 mmol/L. We found no significant correlations between TSC and the monoamine metabolites. High-density lipoprotein cholesterol showed positive correlations with the dopamine metabolite homovanillic acid (r= 0.39, p = 0.04) and the serotonin metabolite 5-hydroxyindoleacetic acid (r = 0.34, p = 0.07). The SIS and HS scales did not correlate significantly with serum lipids. ''Violent'' attempters showed somewhat higher serum lipid levels than ''nonviolent'' attempters. We found no significant differences in serum lipid levels between the diagnostic subgroups. Hence, we could not find much support for the hypothesis of associations between low cholesterol levels and decreased serotonin activity in the brain. However, this field merits further investigation.

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Documento generato il 19/01/20 alle ore 06:08:33