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Titolo:
ALTERED ENDOTHELIUM-MEDIATED RELAXATION BY SYMPATHECTOMY IN ISOLATED RABBIT CAROTID-ARTERY RINGS
Autore:
KAYA T; UTKAN T; SARIOGLU Y; GOKSEL M;
Indirizzi:
CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL SIVAS 58140 TURKEY CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL SIVAS 58140 TURKEY CUMHURIYET UNIV,FAC MED,DEPT NEUROSURG SIVAS 58140 TURKEY
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 6, volume: 17, anno: 1995,
pagine: 369 - 375
SICI:
0379-0355(1995)17:6<369:AERBSI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL SUBARACHNOID HEMORRHAGE; VASCULAR SMOOTH-MUSCLE; VASOACTIVE INTESTINAL POLYPEPTIDE; DEPENDENT VASODILATION; EAR ARTERY; DENERVATION; HEMOGLOBIN; INHIBITION; ADENOSINE; SUBSTANCE;
Keywords:
SYMPATHECTOMY; CAROTID ARTERY; SUBSTANCE P; VIP; ADENOSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
T. Kaya et al., "ALTERED ENDOTHELIUM-MEDIATED RELAXATION BY SYMPATHECTOMY IN ISOLATED RABBIT CAROTID-ARTERY RINGS", Methods and findings in experimental and clinical pharmacology, 17(6), 1995, pp. 369-375

Abstract

The influence of cervical and periarterial sympathectomy on endothelium-dependent and endothelium-independent relaxations of the mature rabbit carotid artery was studied in vitro. The responses to adenosine, vasoactive intestinal polypeptide and substance P in sympathectomized and control rabbit carotid artery rings were recorded and analyzed. Theeffects of endothelium removal were also investigated. The maximal relaxation achieved by substance P, which produces endothelium-dependentrelaxation, was significantly inhibited in 3 weeks in postsympathectomy arterial preparations as compared to controls. Adenosine and vasoactive intestinal polypeptide, which produce endothelium-independent relaxation, elicited similar relaxation in all tissues. These results demonstrated that the response to substance P was impaired by cervical and periarterial sympathectomy. The decreased maximum response to substance P may be the result of a decreased NK-1 receptor subtype density or excitation/response coupling, or it may be due to an impaired production and/or liberation of endothelium-derived relaxing factor (EDRF).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:17:36