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Titolo:
THE ROLE OF RADIOTHERAPY IN THE MANAGEMENT OF SPINAL-CORD GLIOMA
Autore:
SHIRATO H; KAMADA T; HIDA K; KOYANAGI I; IWASAKI Y; MIYASAKA K; ABE H;
Indirizzi:
HOKKAIDO UNIV,SCH MED,DEPT RADIOL,DIV RADIOTHERAPY,KITA KU,N-15 W-7 SAPPORO HOKKAIDO 060 JAPAN HOKKAIDO UNIV,SCH MED,DEPT NEUROSURG SAPPORO HOKKAIDO 060 JAPAN
Titolo Testata:
International journal of radiation oncology, biology, physics
fascicolo: 2, volume: 33, anno: 1995,
pagine: 323 - 328
SICI:
0360-3016(1995)33:2<323:TRORIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTOPERATIVE RADIOTHERAPY; SURGICAL-TREATMENT; RADIATION-THERAPY; EPENDYMOMAS; ASTROCYTOMAS; TUMORS; ADULTS;
Keywords:
SPINAL CORD GLIOMA; RADIOTHERAPY; RADIOCORDECTOMY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
H. Shirato et al., "THE ROLE OF RADIOTHERAPY IN THE MANAGEMENT OF SPINAL-CORD GLIOMA", International journal of radiation oncology, biology, physics, 33(2), 1995, pp. 323-328

Abstract

Purpose: To determine the role of radiotherapy in the management of spinal cord gliomas. Methods and Materials: Thirty-six patients with spinal cord glioma treated between 1979 and 1993 were examined, The patients had 13 astrocytic tumors (7 astrocytomas, 4 anaplastic astrocytomas, 2 glioblastomas), 22 ependymal tumors (18 ependymomas, 4 myxopapillary ependymomas), and 1 unclassified glioma. Fifteen of the patients were treated by surgery alone, but the remainig 21 patients also received postoperative radiotherapy. Total resection was performed on 1 astrocytoma and 13 ependymomas, In general, 40-50 Gy/16-20 fractions/4-5 weeks were given after parital resection, but no radiotherapy was given after total resection. Results: Actuarial survival was significantlybetter for patients with ependymal tumors than for those with astrocytic tumors (p = 0007), 5-year actuarial survival rates being 96% and 50% for patients with ependymal tumors and astrocytic tumors, respectively, For patients with ependymal tumors, there was no difference in motor function and survival between those with total resection and thosewith partial resection followed by radiotherapy, Actuarial 3-year survival was 80% for patients with astrocytomas and 40% for those with anaplastic astrocytomas plus glioblastomas. The difference in the degreeof motor function between the patients treated with radiotherapy and those without radiotherapy was not statistically significant, One anaplastic astrocytoma and one glioblastoma patient have lived longer than4 years after radical treatment including radiocordectomy, or irradiation using doses larger than the tolerance threshold of the spinal cord. Conclusion: Postoperative conventional radiotherapy is indicated after less than total resection of low-grade ependymal tumors and astrocytomas but not after total resection of ependymomas. Radiocordectomy may be an option for certain cases with high-grade astrocytic tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:50:44