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Titolo:
LOW SERUM TRYPTOPHAN TO LARGE NEUTRAL AMINO-ACIDS RATIO IN IDIOPATHICINFANTILE-AUTISM
Autore:
DEUFEMIA P; FINOCCHIARO R; CELLI M; VIOZZI L; MONTELEONE D; GIARDINI O;
Indirizzi:
UNIV ROMA LA SAPIENZA,DEPT PEDIAT,VIALE REGINA ELENA 324 I-00161 ROMEITALY CATHOLIC UNIV ROME,INST NEUROL I-00100 ROME ITALY
Titolo Testata:
Biomedicine & pharmacotherapy
fascicolo: 6, volume: 49, anno: 1995,
pagine: 288 - 292
SICI:
0753-3322(1995)49:6<288:LSTTLN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN; DERIVATIVES; MONOAMINES; DISORDER; ADULTS;
Keywords:
AMINO ACIDS; AUTISM; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
P. Deufemia et al., "LOW SERUM TRYPTOPHAN TO LARGE NEUTRAL AMINO-ACIDS RATIO IN IDIOPATHICINFANTILE-AUTISM", Biomedicine & pharmacotherapy, 49(6), 1995, pp. 288-292

Abstract

The serum tryptophan to large neutral amino acids ratio (Try/LNAA) isconsidered a reliable marker of tryptophan availability for brain serotonin synthesis. A dysfunction of brain serotonergic activity has been postulated to exist in autistic disorder and supported by recent studies. On this basis, we determined the serum amino acids levels in 40 children with idiopathic infantile autism as well as in 46 control children. A significantly lower serum Try/LNAA ratio was observed in the autistic subjects compared to the normal controls. In 14 autistic children (35%) this ratio was 2 SD below the mean value obtained in the control group. These results suggest that a low brain tryptophan avalaibility due to a low serum Try/LNAA ratio could be one of the possible mechanisms involved in the alteration of serotonergic function in autism.

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Documento generato il 12/08/20 alle ore 20:02:47