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Titolo:
INTRAMUSCULAR DEPOT ESTROGEN (ESTRADURIN( R)) IN THE TREATMENT OF PATIENTS WITH PROSTATIC-CARCINOMA HISTORY, MECHANISMS, EFFECTS AND CURRENT CLINICAL STATUS
Autore:
STEGE R; CARLSTROM K; HEDLUND PO; POUSETTE A; VONSCHOULTZ B; HENRIKSSON P;
Indirizzi:
HUDDINGE UNIV HOSP,DEPT UROL S-14186 HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE UNIV KLIN,UROL KLIN HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE UNIV KLIN,GYNAKOL KLIN HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE UNIV KLIN,CHEM KLIN HUDDINGE SWEDEN KAROLINSKA INST,HUDDINGE UNIV KLIN,INNERE MED KLIN HUDDINGE SWEDEN KAROLINSKA INST,KAROLINSKA UNIV KLIN,UROL KLIN STOCKHOLM SWEDEN KAROLINSKA INST,KAROLINSKA UNIV KLIN,GYNAKOL KLIN STOCKHOLM SWEDEN
Titolo Testata:
Der Urologe
fascicolo: 5, volume: 34, anno: 1995,
pagine: 398 - 403
SICI:
0340-2592(1995)34:5<398:IDE(RI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
GER
Soggetto:
POLYESTRADIOL PHOSPHATE; CARDIOVASCULAR COMPLICATIONS; LIPOPROTEIN METABOLISM; PARENTERAL ESTROGEN; HORMONAL TREATMENT; ETHINYL ESTRADIOL; FOLLOW-UP; CANCER; THERAPY; ORCHIDECTOMY;
Keywords:
PROSTATE CANCER; ESTROGEN THERAPY; ESTROGENS; HORMONAL THERAPY; ORAL APPLICATION; PARENTERAL APPLICATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
R. Stege et al., "INTRAMUSCULAR DEPOT ESTROGEN (ESTRADURIN( R)) IN THE TREATMENT OF PATIENTS WITH PROSTATIC-CARCINOMA HISTORY, MECHANISMS, EFFECTS AND CURRENT CLINICAL STATUS", Der Urologe, 34(5), 1995, pp. 398-403

Abstract

More than 50 years ago, orally given estrogen was already used in thetreatment of prostate cancer. Due to cardiovascular side-effects witha high morbidity of 25%, this treatment has not become standard. Recent investigations show that parenteral application reduces the risk ofcardiovascular side-effects, because it avoids the first passage through the liver with high concentrations of estrogen which normally occur after oral application. Therefore, an increased synthesis of so-called ''steroid-sensitive'' Liver proteins, such as coagulation factors (especially factor VII) can be avoided. This newer parenteral estrogen application shows encouraging results of a cheap and effective hormonal therapy with a low rate of side-effects in patients with prostate cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:23:29