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Titolo:
HEALING OF MYOCARDIAL INFARCTS IN DOGS - EFFECTS OF LATE REPERFUSION
Autore:
RICHARD V; MURRY CE; REIMER KA;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PATHOL,BOX 3712 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PATHOL DURHAM NC 27710
Titolo Testata:
Circulation
fascicolo: 7, volume: 92, anno: 1995,
pagine: 1891 - 1901
SICI:
0009-7322(1995)92:7<1891:HOMIID>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY REPERFUSION; ISCHEMIC CELL-DEATH; CARDIAC RUPTURE; WAVEFRONT PHENOMENON; TIME COURSE; 90 MINUTES; PMN INFLUX; EXPANSION; SIZE; STREPTOKINASE;
Keywords:
ISCHEMIA; REPERFUSION; MYOCARDIAL INFARCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
V. Richard et al., "HEALING OF MYOCARDIAL INFARCTS IN DOGS - EFFECTS OF LATE REPERFUSION", Circulation, 92(7), 1995, pp. 1891-1901

Abstract

Background Early reperfusion salvages ischemic myocardium and limits myocardial infarct size. However, the effects of late reperfusion, after the possibility for limitation of infarct size has passed, have notbeen completely elucidated. The purpose of this study was to ascertain the effect of reperfusion after 6 hours of ischemia on the rate of infarct healing and on the size and geometry of the resulting scars, asdetermined by gross and microscopic quantification. Methods and Results Myocardial infarcts were produced in anesthetized, open-chest dogs by occlusion of the circumflex coronary artery. They either were reperfused by removal of the occluding snare or were nonreperfused. The animals were allowed to recover for either 4 days, 2 weeks, or 6 weeks. At these times, infarct size, infarct dimensions (wall thickness and circumferential extent), and the proportion of infarct occupied by necrotic myocardium versus granulation tissue (evolving scar) were measured. At 4 days, infarcts were swollen in both nonreperfused and reperfused groups (increased thickness and circumferential extent of the area at risk). Conversely, at 6 weeks, the size, thickness, and circumferential extent of the scar all were decreased. Two common anatomic complications of human infarction, cardiac rupture and chronic infarct expansion (aneurysm), did not occur in this experimental model. Reperfusion at 6 hours did not affect initial infarct size (4 days) or scar size (6 weeks). At 2 weeks, reperfused infarcts were smaller and were composed of proportionately more granulation tissue and less nonresorbed necrosis than nonreperfused infarcts. Conclusions Thus, reperfusion accelerated the rate of infarct repair, ie, the replacement of necrotic myocardium by scar. Acceleration of infarct repair may be a beneficial effect of late reperfusion even after the opportunity for limitation of infarct size has passed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:03:12