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Titolo:
EVALUATION OF A 2-PHASE SCID MOUSE MODEL PRECONDITIONED WITH ANTI-INTERFERON-GAMMA MONOCLONAL-ANTIBODY FOR DRUG-TESTING AGAINST CRYPTOSPORIDIUM-PARVUM
Autore:
TZIPORI S; RAND W; THEODOS C;
Indirizzi:
TUFTS UNIV,SCH VET MED,DEPT COMPARAT MED,DIV INFECT DIS,200 WESTBORO RD N GRAFTON MA 01536 TUFTS UNIV,DEPT COMMUNITY HLTH BOSTON MA 00000
Titolo Testata:
The Journal of infectious diseases
fascicolo: 4, volume: 172, anno: 1995,
pagine: 1160 - 1164
SICI:
0022-1899(1995)172:4<1160:EOA2SM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICE; INFECTION; NUDE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S. Tzipori et al., "EVALUATION OF A 2-PHASE SCID MOUSE MODEL PRECONDITIONED WITH ANTI-INTERFERON-GAMMA MONOCLONAL-ANTIBODY FOR DRUG-TESTING AGAINST CRYPTOSPORIDIUM-PARVUM", The Journal of infectious diseases, 172(4), 1995, pp. 1160-1164

Abstract

One 1-mg injection of anti-interferon-gamma monoclonal antibody (anti-IFN-gamma MAb) into newly weaned scid mice 2 h before challenge with Cryptosporidium parvum oocysts markedly exacerbated the course of the infection for greater than or equal to 47 days, compared with challenged mice that received an equivalent dose of irrelevant MAb. Oocyst excretion in feces started 4-6 days after challenge and continued at highlevels for greater than or equal to 47 days. Loss of body weight was also apparent. The extent and distribution of mucosal infection were profound, involving the stomach and several segments of the small and large intestines. The acute phase, which involved infection of the gut,was during the first 25 days after challenge. The following chronic phase consistently involved, in addition, infection of the hepatobiliary tract. The acute phase is a useful model in which to test luminally active drugs, while the chronic phase may be used in the future to test drugs that are active against hepatobiliary tract infections as well.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:44:44