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Titolo:
INTERMEDIATE FILAMENTS AND CYTOPLASMIC NETWORKING - NEW CONNECTIONS AND MORE FUNCTIONS
Autore:
CHOU YH; SKALLI O; GOLDMAN RD;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT CELL & MOL BIOL,303 E CHICAGO AVE CHICAGO IL 60611 UNIV ILLINOIS,DEPT ANAT & CELL BIOL CHICAGO IL 60612
Titolo Testata:
Current opinion in cell biology
fascicolo: 1, volume: 9, anno: 1997,
pagine: 49 - 53
SICI:
0955-0674(1997)9:1<49:IFACN->2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; KERATIN; HEMIDESMOSOMES; IDENTIFICATION; VIMENTIN; DISEASE; BINDING; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Y.H. Chou et al., "INTERMEDIATE FILAMENTS AND CYTOPLASMIC NETWORKING - NEW CONNECTIONS AND MORE FUNCTIONS", Current opinion in cell biology, 9(1), 1997, pp. 49-53

Abstract

Recent research highlights the roles of cytoskeletal intermediate filaments (Ifs) and their interactions with both the cell surface and other cytoskeletal systems in maintaining cellular integrity and the mechanical properties of cytoplasm. This has been demonstrated by analysesof mutations in If-associated proteins (IFAPs) that are involved in connecting Ifs to cell surface junctions. New data also point to the role of IFAPs as molecular 'nuts and bolts' in the construction of an integrated cytoplasmic architecture. This is highlighted by the initial descriptions of a family of multifunctional molecules that are capableof bridging Ifs to other cytoskeletal elements. These findings, together with the development of specific peptide inhibitors capable of disassembling IF networks in vivo, are paving the way to the identification of new cellular functions for Ifs and IFAPs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 17:16:09