Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PROTEIN-KINASE-A REGULATES THE DEGRADATION RATE OF RS ACETYLCHOLINE-RECEPTORS
Autore:
XU RF; SALPETER MM;
Indirizzi:
CORNELL UNIV,DIV BIOL SCI,NEUROBIOL & BEHAV SECT,W113 SG MUDD HALL ITHACA NY 14853 CORNELL UNIV,DIV BIOL SCI,NEUROBIOL & BEHAV SECT ITHACA NY 14853
Titolo Testata:
Journal of cellular physiology
fascicolo: 1, volume: 165, anno: 1995,
pagine: 30 - 39
SICI:
0021-9541(1995)165:1<30:PRTDRO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; VERTEBRATE NEUROMUSCULAR-JUNCTIONS; SPINAL-CORD MOTONEURONS; CYCLIC-AMP; METABOLIC STABILIZATION; SELECTIVE INHIBITOR; MUSCLE-ACTIVITY; PHOSPHORYLATION; CHANNELS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
R.F. Xu e M.M. Salpeter, "PROTEIN-KINASE-A REGULATES THE DEGRADATION RATE OF RS ACETYLCHOLINE-RECEPTORS", Journal of cellular physiology, 165(1), 1995, pp. 30-39

Abstract

Acetylcholine receptors at the neuromuscular junction of innervated vertebrate muscle (called Rs AChRs) have a stable degradation rate (t(1/2) similar to 8-12 days) which accelerates after denervation to a half-life of similar to 3 days, but can be restabilized by reinnervation or by cAMP. We examined the mechanism by which cAMP regulates the Rs degradation rate. When dibutyryl cAMP (DB-cAMP) was applied to denervated mouse diaphragms in organ culture, it stabilized the accelerated degradation rate of the Rs. We found that this stabilization is reversible upon removal of the DB-cAMP, is cAMP specific and is mediated by intracellular cAMP. A major observation of this study is that the cAMP-induced stabilization of Rs AChRs is via protein kinase A (PKA), since H89, a PKA inhibitor, blocked the DB-cAMP induced stabilization of Rs,and H85, an analog of H89, which does not inhibit PKA but does inhibit other kinases as efficiently as H89, did not prevent the DB-cAMP-induced stabilization of Rs degradation. These results suggest that the cAMP messenger system via a PKA-dependent pathway could be among the mechanisms whereby the nerve regulates AChR degradation. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 16:18:29