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Titolo:
IMPAIRMENT OF BLOOD-BRAIN-BARRIER FUNCTION BY SEROTONIN INDUCES DESYNCHRONIZATION OF SPONTANEOUS CEREBRAL CORTICAL ACTIVITY - EXPERIMENTAL-OBSERVATIONS IN THE ANESTHETIZED RAT
Autore:
WINKLER T; SHARMA HS; STALBERG E; OLSSON Y; DEY PK;
Indirizzi:
UNIV UPPSALA HOSP,NEUROPATHOL LAB S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,NEUROPATHOL LAB S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT CLIN NEUROPHYSIOL S-75185 UPPSALA SWEDEN BANARAS HINDU UNIV,INST MED SCI,DEPT PHYSIOL,NEUROPHYSIOL RES UNIT VARANASI 221005 UTTAR PRADESH INDIA
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 68, anno: 1995,
pagine: 1097 - 1104
SICI:
0306-4522(1995)68:4<1097:IOBFBS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LUMBAR CEREBROSPINAL-FLUID; NORMOTENSIVE YOUNG-RATS; SPINAL-CORD; VESTIBULAR NUCLEUS; FLOW; PERMEABILITY; NEURONS; EDEMA; 5-HYDROXYTRYPTAMINE; METABOLITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
T. Winkler et al., "IMPAIRMENT OF BLOOD-BRAIN-BARRIER FUNCTION BY SEROTONIN INDUCES DESYNCHRONIZATION OF SPONTANEOUS CEREBRAL CORTICAL ACTIVITY - EXPERIMENTAL-OBSERVATIONS IN THE ANESTHETIZED RAT", Neuroscience, 68(4), 1995, pp. 1097-1104

Abstract

The possibility that elevation of serotonin in the circulation, whichis found in various pathological states, influences the spontaneous cerebral cortical activity was examined in a rat model. The electroencephalogram was recorded using bipolar epidural electrodes placed over the frontal and parietal cerebral cortex. Intravenous infusion of serotonin (10 mu g/kg per min for 10 min) decreased the electroencephalogram amplitude in both frontal and parietal recordings within 4 min of infusion. This decrease in amplitude was reversible. Pretreatment with cyproheptadine (a potent serotonin(2) receptor antagonist) prevented the serotonin-induced decrease of the electroencephalogram amplitude. The blood-brain barrier permeability to Evans Blue and [I-131]sodium wasincreased in frontal and parietal cortex. This increase in blood-brain barrier permeability was absent in animals pretreated with cyproheptadine. These results provide direct evidence that an elevated level ofserotonin in blood has the capacity to influence spontaneous corticalelectrical activity. This effect of serotonin on electroencephalogramappears to be due to its ability to enter into the brain parenchyma by inducing a short-term breakdown of the blood-brain barrier, probablyvia serotonin(2) receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 21:53:41