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Titolo:
GLUCOSE INJECTIONS INTO THE MEDIAL SEPTUM REVERSE THE EFFECTS OF INTRASEPTAL MORPHINE INFUSIONS ON HIPPOCAMPAL ACETYLCHOLINE OUTPUT AND MEMORY
Autore:
RAGOZZINO ME; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,LIFE SCI LABS,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL,LIFE SCI LABS CHARLOTTESVILLE VA 22903
Titolo Testata:
Neuroscience
fascicolo: 4, volume: 68, anno: 1995,
pagine: 981 - 988
SICI:
0306-4522(1995)68:4<981:GIITMS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCOPOLAMINE-INDUCED AMNESIA; SPONTANEOUS-ALTERNATION; RAT-BRAIN; WORKING MEMORY; BETA-ENDORPHIN; ELDERLY HUMANS; MICE; ENHANCEMENT; ATTENUATION; AREA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Ragozzino e P.E. Gold, "GLUCOSE INJECTIONS INTO THE MEDIAL SEPTUM REVERSE THE EFFECTS OF INTRASEPTAL MORPHINE INFUSIONS ON HIPPOCAMPAL ACETYLCHOLINE OUTPUT AND MEMORY", Neuroscience, 68(4), 1995, pp. 981-988

Abstract

Morphine infusions into the medial septum produce memory deficits which can be attenuated by concurrent intraseptal injections of glucose. The mnemonic deficits following intraseptal morphine injections may bedue, in part, to opioid inhibition of cholinergic neurons projecting to the hippocampus, with glucose reducing this effect. The present experiment determined whether glucose injections into the medial septum attenuate the effects of intraseptal morphine injections on hippocampalacetylcholine release and on memory. Samples of extracellular acetylcholine levels were assessed at 12-min intervals using in vivo microdialysis with high-performance liquid chromatography with electrochemicaldetection. Intraseptal morphine injections (4.0 nmol) reduced acetylcholine output starting at 12 min and lasting up to 72 min post-injection. Glucose (18.3 nmol) injected concomitantly with morphine reversed the morphine-induced decrease in acetylcholine output. Several days after microdialysis testing, rats received drug infusions in the septum 20 min prior to spontaneous alternation testing. Intraseptal morphine infusions reduced alternation scores; this behavioral effect was reversed by concurrent glucose infusions. The effects of drugs infused intothe septal area on spontaneous alternation performance and acetylcholine output were positively correlated. These findings suggest that memory deficits induced by intraseptal morphine injections may result, atleast partially, from a decrease in the activity of cholinergic neurons and that this effect is reversed by glucose.

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Documento generato il 02/07/20 alle ore 19:10:13