Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
REGULATION OF EXPRESSION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR) GENE - A CENTRAL ROLE FOR STEROIDOGENIC FACTOR-1
Autore:
SUGAWARA T; KIRIAKIDOU M; MCALLISTER JM; HOLT JA; ARAKANE F; STRAUSS JF;
Indirizzi:
UNIV PENN,MED CTR,CTR RES REPROD & WOMENS HLTH,778 CLIN RES BLDG,415 CURIE BLVD PHILADELPHIA PA 19104 UNIV PENN,MED CTR,CTR RES REPROD & WOMENS HLTH PHILADELPHIA PA 19104 PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT MED,DIV ENDOCRINOL HERSHEY PA 17033 PENN STATE UNIV,MILTON S HERSHEY MED CTR,DEPT CELL & MOL PHYSIOL,DIV ENDOCRINOL HERSHEY PA 17033
Titolo Testata:
Steroids
fascicolo: 1, volume: 62, anno: 1997,
pagine: 5 - 9
SICI:
0039-128X(1997)62:1<5:ROEOTS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELLS;
Keywords:
STAR GENE; STEROIDOGENIC FACTOR 1; CAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
T. Sugawara et al., "REGULATION OF EXPRESSION OF THE STEROIDOGENIC ACUTE REGULATORY PROTEIN (STAR) GENE - A CENTRAL ROLE FOR STEROIDOGENIC FACTOR-1", Steroids, 62(1), 1997, pp. 5-9

Abstract

Steroidogenic acute regulatory protein (StAR) plays a critical role in regulating the rate-limiting step in steroid hormone synthesis, cholesterol side-chain cleavage. StAR gene expression is transcriptionallycontrolled in the gonads by gonadotropic hormones via a cAMP second message. We have begun to analyze factors responsible for the transcriptional activation of the StAR gene. The human SrAR gene promoter has at least two cis elements that govern basal and cAMP-regulated gene expression. One of these elements (the distal element) is a consensus binding sequence for the orphan nuclear receptor transcription factor, steroidogenic factor 1 (SF-1); the other (the proximal element) is a related motif. The human StAR promoter is not active in BeWo choriocarcinoma cells, but is functional and cAMP-responsive in murine Y1 adrenal cortical tumor cells. Cotransfection of a plasmid expressing SF-1 allows a StAR promoter construct to function in BeWo cells. Other orphan nuclear transcription factors do not support StAR promoter function in BeWo cell hosts. Deletion or mutation of the distal and proximal cis elements individually substantially reduces SF-1-supported StAR promoter activity The distal site binds SF-1 with high affinity whereas the proximal site binds SF-1 with lower affinities. These findings demonstrate a requirement for SF-1 for human StAR gene expression. (C) 1997 byElsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 16:08:26