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Titolo:
OPPOSITE ROLE OF CCKA AND CCKB RECEPTORS IN THE MODULATION OF ENDOGENOUS ENKEPHALIN ANTIDEPRESSANT-LIKE EFFECTS
Autore:
SMADJA C; MALDONADO R; TURCAUD S; FOURNIEZALUSKI MC; ROQUES BP;
Indirizzi:
UFR SCI PHARMACEUT & BIOL,DEPT PHARMACOCHIM MOLEC & STRUCT,CNRS,URA D1500,INSERM,U266 F-75270 PARIS 06 FRANCE UFR SCI PHARMACEUT & BIOL,DEPT PHARMACOCHIM MOLEC & STRUCT,CNRS,URA D1500,INSERM,U266 F-75270 PARIS 06 FRANCE
Titolo Testata:
Psychopharmacology
fascicolo: 4, volume: 120, anno: 1995,
pagine: 400 - 408
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPEPTIDE CHOLECYSTOKININ ANTAGONIST; H-3 PBC 264; B RECEPTOR; RAT-BRAIN; CONDITIONED SUPPRESSION; REGULATORY MECHANISMS; MORPHINE ANALGESIA; NUCLEUS-ACCUMBENS; DEGRADING-ENZYMES; OPIOID RECEPTORS;
Keywords:
CONDITIONED SUPPRESSION OF MOTILITY; ANTIDEPRESSANT-LIKE EFFECTS; ENKEPHALIN-DEGRADING ENZYMES; RB 101; L-365,260; BC 264; L-364,718; DELTA-OPIOID RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C. Smadja et al., "OPPOSITE ROLE OF CCKA AND CCKB RECEPTORS IN THE MODULATION OF ENDOGENOUS ENKEPHALIN ANTIDEPRESSANT-LIKE EFFECTS", Psychopharmacology, 120(4), 1995, pp. 400-408

Abstract

Systemic administration of RB 101, a complete inhibitor of the enkephalin degrading enzymes, has been reported to induce naltrindole-reversed antidepressant-like effects in the conditioned suppression of motility (CSM) test in mice. The selective CCKB antagonist L-365,260 also elicits the same naltrindole-blocked responses on CSM. The aim of this study was therefore to investigate the possible modulation of RE 101 induced behavioral responses by activation or blockade of CCK receptors. Thus, the effects induced by RE 101 administered alone or associatedwith an ineffective dose of a selective CCKB agonist (BC 264), a CCKBantagonist (L-365,260) or a CCKA antagonist (L-364,718), were evaluated on the CSM in mice. RE 101 alone decreased the stress-induced loss of motility, as previously reported. The antidepressant-like effect ofRE 101 was potentiated by L-365,260, and suppressed by BC 264 and to a lesser extent by L-364,718. The facilitatory effect induced by L-365,260 on RE 101 responses was blocked by the delta selective antagonistnaltrindole. All these effects occurred only in shocked animals. The present results suggest that the activation of CCKA and CCKB receptorsby endogenous CCK, could play an opposite role in the control of behavioral responses induced by endogenous enkephalins. Delta opioid receptors seem to be selectively involved in this interaction.

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Documento generato il 30/11/20 alle ore 14:47:26