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Titolo:
HOW EFFECTIVE IS ENTERAL NUTRITION IN INDUCING CLINICAL REMISSION IN ACTIVE CROHNS-DISEASE - A METAANALYSIS OF THE RANDOMIZED CLINICAL
Autore:
FERNANDEZBANARES F; CABRE E; ESTEVECOMAS M; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL,CARRETERA CANYET S-N E-08916 BADALONA SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL E-08916 BADALONA SPAIN
Titolo Testata:
JPEN. Journal of parenteral and enteral nutrition
fascicolo: 5, volume: 19, anno: 1995,
pagine: 356 - 364
SICI:
0148-6071(1995)19:5<356:HEIENI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; DEFINED-FORMULA DIET; CONTROLLED TRIAL; ELEMENTAL DIET; PRIMARY THERAPY; DRUG-TREATMENT; PREDNISOLONE; METAANALYSIS; ACID; REST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
F. Fernandezbanares et al., "HOW EFFECTIVE IS ENTERAL NUTRITION IN INDUCING CLINICAL REMISSION IN ACTIVE CROHNS-DISEASE - A METAANALYSIS OF THE RANDOMIZED CLINICAL", JPEN. Journal of parenteral and enteral nutrition, 19(5), 1995, pp. 356-364

Abstract

Background: The purpose of the study was to evaluate, using meta-analysis techniques, whether enteral nutrition is effective in inducing clinical remission in active Crohn's disease. Methods: Randomized trialseither comparing enteral nutrition with steroids or comparing elemental (amino acid-based) with nonelemental diets were selected using MEDLINE (1984 to 1994), reference lists from published articles, reviews, and abstracts from major gastrointestinal meetings. Sixteen studies fulfilled the inclusion criteria (four published as abstracts). Crude rates for induction of remission were collected on an intention-to-treatbasis by three independent observers. Each study was given a quality score, based on predetermined criteria. Results: The pooled odds ratio(OR) for all type of enteral diets compared with steroid therapy was 0.35 (95% CI, 0.23 to 0.53). This result was similar for the best studies (by quality score) combined, for trials using tube feeding combined, and when noncompliant patients were withdrawn. Further subgroup analyses were conducted on the basis of the type of diet administered. Peptide-based diets were significantly inferior to steroids (pooled OR, 0.32; CI, 0.20 to 0.52). There was a trend to lower remission rate after elemental diets than after steroids (pooled OR, 0.44; CI 0.17 to 1.12). On the other hand, pooled OR for whole protein-based diets compared with elemental diets was 1.28 (CI, 0.40 to 4.02). Conclusions: Dataavailable to date show that steroids are better than enteral nutrition to induce remission in active Crohn's disease. These results are more evident when peptide-based diets are administered, but they are not conclusive when either elemental or whole protein-based diets are used.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 01:02:42