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Titolo:
OXIDIZED LDL INDUCE HSP70 EXPRESSION IN HUMAN SMOOTH-MUSCLE CELLS
Autore:
ZHU WM; ROMA P; PIRILLO A; PELLEGATTA F; CATAPANO AL;
Indirizzi:
UNIV MILAN,INST PHARMACOL SCI,VIA BALZARETTI 9 I-20133 MILAN ITALY UNIV MILAN,INST PHARMACOL SCI I-20133 MILAN ITALY UNIV MILAN,CTR STUDIO PREVENZ & TERAPIA VASCULOPATIE ATEROSC MILAN ITALY IST SCI SAN RAFFAELE,CARDIOVASC PHYSIOPATHOL LAB MILAN ITALY
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 372, anno: 1995,
pagine: 1 - 5
SICI:
0014-5793(1995)372:1<1:OLIHEI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; HEAT-SHOCK; ATHEROSCLEROSIS; PATHOGENESIS; PROTEINS; LOCALIZATION; CHOLESTEROL; SURVIVAL; CULTURE; GROWTH;
Keywords:
HUMAN SMOOTH CELL; HEAT SHOCK PROTEIN 70; OXIDIZED-LDL; CYTOTOXICITY; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
W.M. Zhu et al., "OXIDIZED LDL INDUCE HSP70 EXPRESSION IN HUMAN SMOOTH-MUSCLE CELLS", FEBS letters, 372(1), 1995, pp. 1-5

Abstract

Heat shock protein 70 (hsp70) has been detected in atherosclerotic lesions, in which endothelial cells and smooth muscle cells are involved, In a previous report we showed that Ox-LDL, a causal factor in atherosclerosis, could induce hsp70 expression in cultured human endothelial cells [Zhu et al, B,B,R,C 1994, 200:389], Here, with immunofluorescence and immunoblotting techniques, we show that Ox-LDL are capable of inducing hsp70 expression also in human smooth muscle cells, and that this induction is dependent on cell density and on the concentration of Ox-LDL, The induced expression of hsp70 was higher in human umbilical vein smooth muscle cells than in a human smooth muscle cell line, Conversely, Ox-LDL was cytotoxic to both types of cells, more so to the human smooth muscle cell line, These observations indicate that Ox-LDLmay be a stress responsible for hsp70 expression in atherosclerotic plaques and the presence of hsp70 in plaques may be a useful marker forcontinuous oxidative damage in the arterial mall.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:36:52