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Titolo:
EXPERIMENTALLY-INDUCED DISORDERS OF NEURONAL MIGRATION PRODUCE AN INCREASED PROPENSITY FOR ELECTROGRAPHIC SEIZURES IN RATS
Autore:
ROPER SN; GILMORE RL; HOUSER CR;
Indirizzi:
UNIV FLORIDA,COLL MED,DEPT NEUROL SURG,POB 100265 GAINESVILLE FL 32610 UNIV FLORIDA,COLL MED,DEPT NEUROL GAINESVILLE FL 32610 UNIV CALIF LOS ANGELES,BRAIN RES INST,DEPT ANAT & CELL BIOL LOS ANGELES CA 90024
Titolo Testata:
Epilepsy research
fascicolo: 3, volume: 21, anno: 1995,
pagine: 205 - 219
SICI:
0920-1211(1995)21:3<205:EDONMP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRACTABLE PARTIAL EPILEPSY; CORTICAL DYSPLASIA; NEUROPATHOLOGIC FINDINGS; SURGICAL-TREATMENT; CEREBRAL-CORTEX; FETAL RATS; NEOCORTEX; METHYLAZOXYMETHANOL; ANOMALIES; SPECTRUM;
Keywords:
BRAIN DEVELOPMENT; SEIZURE; NEOCORTEX; RADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
S.N. Roper et al., "EXPERIMENTALLY-INDUCED DISORDERS OF NEURONAL MIGRATION PRODUCE AN INCREASED PROPENSITY FOR ELECTROGRAPHIC SEIZURES IN RATS", Epilepsy research, 21(3), 1995, pp. 205-219

Abstract

Disorders of neuronal migration in humans are associated with intractable epilepsy and some evidence suggests a causal relationship. This study evaluated electroencephalograms (EEG) of rats with experimentallyinduced disorders of neuronal migration. Fetal Sprague-Dawley rats were exposed to 196 cGy external irradiation on days 16 and 17 of gestation. This produced adult offspring with diffuse cortical dysplasias, agenesis of the corpus callosum, periventricular heterotopias, and dispersion of the pyramidal cell layer of the hippocampus. Epidural electrodes were implanted in four experimental (irradiated on gestational day 17) and four control rats. EEGs were recorded without anesthesia andin the presence of the anesthetic agents ketamine, acepromazine, and xylazine. In the presence of acepromazine, xylazine, or a combination of the two drugs, two of the four experimental rats had prolonged ictal activity on EEG. In one of the rats the ictal activity progressed toelectrographic status epilepticus. Ketamine alone did not produce ictal EEG activity. None of the control rats demonstrated ictal activity under any treatment condition. This study demonstrates that disorders of neuronal migration are associated with an increased propensity for seizures in the presence of certain sedating agents.

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Documento generato il 25/11/20 alle ore 10:30:47