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Titolo:
INCREASED DENSITY OF DOPAMINE D2 RECEPTORS IN THE PUTAMEN, BUT NOT INTHE CAUDATE-NUCLEUS IN EARLY PARKINSONS-DISEASE - A PET STUDY WITH [C-11] RACLOPRIDE
Autore:
RINNE JO; LAIHINEN A; RUOTTINEN H; RUOTSALAINEN U; NAGREN K; LEHIKOINEN P; OIKONEN V; RINNE UK;
Indirizzi:
UNIV TURKU,DEPT NEUROL SF-20520 TURKU FINLAND UNIV TURKU,CYCLOTRON PET CTR TURKU FINLAND UNIV TURKU,CYCLOTRON PET CTR,RADIOPHARMACEUT CHEM LAB TURKU FINLAND
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 132, anno: 1995,
pagine: 156 - 161
SICI:
0022-510X(1995)132:2<156:IDODDR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 RACLOPRIDE; BRAIN DOPAMINE; BINDING; MPTP; INVIVO; SUPERSENSITIVITY; HUNTINGTON; FLUORODOPA; SYSTEM;
Keywords:
DOPAMINE RECEPTORS; D2 RECEPTORS; PARKINSONS DISEASE; POSITRON EMISSION TOMOGRAPHY; RACLOPRIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
J.O. Rinne et al., "INCREASED DENSITY OF DOPAMINE D2 RECEPTORS IN THE PUTAMEN, BUT NOT INTHE CAUDATE-NUCLEUS IN EARLY PARKINSONS-DISEASE - A PET STUDY WITH [C-11] RACLOPRIDE", Journal of the neurological sciences, 132(2), 1995, pp. 156-161

Abstract

Striatal dopamine D2 receptors were studied, using positron emission tomography (PET), in 10 patients with early Parkinson's disease without any antiparkinsonian medication and in 14 healthy controls. [C-11]Raclopride was used as ligand and an equilibrium method was applied. Themaximum count of receptors (B-max) and their dissociation constant (K-d) were calculated according to the Scatchard principle. In parkinsonian patients, the B-max of D2 receptors was increased in the putamen contralateral to the predominant symptoms, as compared to the opposite putamen, by 33% (p = 0.0008). In the caudate nucleus no significant side to side differences was noted. On comparison with age-matched healthy controls, B-max values in the putamen (p = 0.0012) but not in the caudate nucleus contralateral to the side of predominant clinical symptoms were increased in PD patients. The K-d values were unchanged. The difference in putaminal B-max values between the opposite hemispheres correlated with the difference in the severity of parkinsonian motor symptoms between the two body sides (r = 0.69, p = 0.03). The present results show that there is both a relative and absolute increase in thenumber of dopamine D2 receptors in the putamen, but not in the caudate nucleus in early Parkinson's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 07:03:14