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Titolo:
EFFECTS OF A CONTINUOUS-INFUSION OF DOPAMINE ON THE VENTILATORY AND CAROTID-BODY RESPONSES TO HYPOXIA IN CATS
Autore:
IDE T; SHIRAHATA M; CHOU CL; FITZGERALD RS;
Indirizzi:
JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,DEPT ENVIRONM HLTH SCI,615 N WOLFE ST BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT ENVIRONM HLTH SCI BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT ANESTHESIOL CRIT CARE MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT PHYSIOL & MED BALTIMORE MD 21205
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 9, volume: 22, anno: 1995,
pagine: 658 - 664
SICI:
0305-1870(1995)22:9<658:EOACOD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMANS; DRIVE;
Keywords:
CAROTID BODY; CATECHOLAMINE; CHEMORECEPTOR; DOPAMINE; HYPOXIA; HYPOXIC RESPONSE; VENTILATION; VENTILATORY; RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
T. Ide et al., "EFFECTS OF A CONTINUOUS-INFUSION OF DOPAMINE ON THE VENTILATORY AND CAROTID-BODY RESPONSES TO HYPOXIA IN CATS", Clinical and experimental pharmacology and physiology, 22(9), 1995, pp. 658-664

Abstract

1. We investigated how a continuous infusion of dopamine (DA; 5 mu g/kg per min), which is often used clinically, would affect the ventilation and carotid chemoreceptor neural activity in anaesthetized cats. 2. In anaesthetized, spontaneously breathing cats, tidal volume (V-T) and respiratory frequency (f) were continuously monitored at five levels of inspired oxygen (P-IO2 = 110, 130, 150, 170, 760 mmHg) during Da or saline infusion. V-T and f were sampled for 1 min after 3 min exposure to each level of P-IO2. Time control study was also performed. 3. DA infusion significantly lowered V-T under both normoxia and hypoxia in seven of eight cats. Respiratory frequency was not affected by DA infusion. Depression of ventilation during post-hypoxic hyperoxia was augmented by DA infusion, Chemodenervation abolished the ventilatory response to hypoxia and DA did not further affect the ventilatory response to hypoxia. 4. In a second group of artificially ventilated cats, carotid chemoreceptor neural activity was recorded at five levels of arterial oxygen tension. DA infusion significantly depressed carotid chemoreceptor neural activity during normoxia and hypoxia in six of sevencats. 5. These findings suggest that changes in ventilation during low dosage of DA infusion closely correlate with carotid body neural output, A predominant effect of this dosage of DA (5 mu g/kg per min) wasdepression in the ventilatory response to hypoxia due to an inhibition of carotid body neural output.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:29:05