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Titolo: IMMUNODEFICIENCY IN IL-2-KNOCKOUT MICE
Autore: HORAK I;
- Indirizzi:
- UNIV WURZBURG,INST VIROL & IMMUNOBIOL,VERSBACHER STR 7 D-97078 WURZBURG GERMANY
- Titolo Testata:
- Clinical immunology and immunopathology
fascicolo: 3,
volume: 76,
anno: 1995,
parte:, 2
pagine: 172 - 173
- SICI:
- 0090-1229(1995)76:3<172:IIIM>2.0.ZU;2-X
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- INFLAMMATORY BOWEL-DISEASE; INTERLEUKIN-2; GENE; CELLS;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Science Citation Index Expanded
- Citazioni:
- 18
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- I. Horak, "IMMUNODEFICIENCY IN IL-2-KNOCKOUT MICE", Clinical immunology and immunopathology, 76(3), 1995, pp. 172-173
Abstract
Interleukin-2-deficient mice (IL-2(-/-)) generated by targeted mutagenesis proved to be an excellent system to study the function of this lymphokine in the context of whole immune system. In addition, they provide an animal model of a primary immunodeficiency caused by a single-gene defect. Our results indicate that the essential degect in IL-2(-/-) mice is the lack of a negative regulatory function, which leads to breakdown of self tolerance. The development of autoimmune diseases inIL-2-deficient mice stresses the link between autoimmunity and primary immunodeficiencies. (C) 1995 Academic Press, Inc.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 15:48:24