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Titolo:
PATTERN-REVERSAL VISUAL-EVOKED RESPONSE IN BULLS EYE MACULOPATHY ASSOCIATED WITH STARGARDTS-DISEASE
Autore:
WAJIMA R; KATSUMI O; MEHTA MC; ITABASHI R; HIROSE T;
Indirizzi:
HARVARD UNIV,SCH MED,DEPT OPHTHALMOL,SCHEPENS EYE RES INST,DEPT OPHTHALMOL,100 CHARLES RIVER PL BOSTON MA 02114 HARVARD UNIV,SCH MED,DEPT OPHTHALMOL,SCHEPENS EYE RES INST,DEPT OPHTHALMOL BOSTON MA 02114
Titolo Testata:
Ophthalmic research
fascicolo: 4, volume: 27, anno: 1995,
pagine: 234 - 242
SICI:
0030-3747(1995)27:4<234:PVRIBE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUITY; POTENTIALS;
Keywords:
AMPLITUDE-CHECK SIZE FUNCTION; BULLS EYE MACULOPATHY; CRITICAL FLICKER FREQUENCY; PATTERN-REVERSAL VISUAL EVOKED RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
R. Wajima et al., "PATTERN-REVERSAL VISUAL-EVOKED RESPONSE IN BULLS EYE MACULOPATHY ASSOCIATED WITH STARGARDTS-DISEASE", Ophthalmic research, 27(4), 1995, pp. 234-242

Abstract

Using steady-state pattern-reversal visual-evoked response (PVER), westudied the macular function in patients with bull's eye maculopathy. The results were correlated with fluerescein angiography. Study patients with an established (25 eyes of 14 patients) and a suspected (8 eyes of 4 patients) diagnosis of Stargardt's disease with bull's eye maculopathy were divided into group G (good vision group: 15 eyes with visual acuity of 20/40 or better) and group P (poor vision group: 18 eyes with visual acuity of 20/50 or worse). The diameters of the atrophicarea and the normal or less affected central area of the bull's eye were measured from the fluorescein angiograms. The mean diameter of thecentral area in group G (2.0 degrees) was significantly larger than that in group P (0.6 degrees; d.f. = 17, p = 0.0227). The PVER amplitudes were reduced in the patient groups with all check sizes and the amplitude-check size functions were flat. Amplitude differences were observed between the patient groups with the 20' checks (d.f. = 17, p = 0.0638), probably due to the difference in the mean central diameters (2.0 degrees vs. 0.6 degrees). Patients with a perifoveal abnormality can have an abnormal PVER despite relatively good visual acuity. We alsorecorded the PVER in 7 normal controls tested with simulated ring-shaped scotomas, the sizes of which matched the mean diameters of the scotomas in the patient groups (7.0 degrees x 0.6 degrees and 7.0 degreesx 2.0 degrees). The controls also showed markedly reduced responses with all check sizes. With the 10-min check, a significant difference was seen between controls tested with the two scotoma sizes, simulatingthe two patient groups. The amplitude-check size function in bull's eye maculopathy flattened even in those whose vision was relatively good.

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Documento generato il 25/11/20 alle ore 18:20:45