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Titolo:
INTERACTION OF TYROSINE-BASED SORTING SIGNALS WITH CLATHRIN-ASSOCIATED PROTEINS
Autore:
OHNO H; STEWART J; FOURNIER MC; BOSSHART H; RHEE I; MIYATAKE S; SAITO T; GALLUSSER A; KIRCHHAUSEN T; BONIFACINO JS;
Indirizzi:
NICHHD,CELL BIOL & METAB BRANCH BETHESDA MD 20892 NICHHD,CELL BIOL & METAB BRANCH BETHESDA MD 20892 HARVARD UNIV,SCH MED,DEPT CELL BIOL BOSTON MA 02115 HARVARD UNIV,SCH MED,CTR BLOOD RES BOSTON MA 02115 CHIBA UNIV,SCH MED,CTR BIOMED SCI,DIV MOLEC GENET CHIBA 260 JAPAN
Titolo Testata:
Science
fascicolo: 5232, volume: 269, anno: 1995,
pagine: 1872 - 1875
SICI:
0036-8075(1995)269:5232<1872:IOTSSW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANS-GOLGI NETWORK; PLASMA-MEMBRANE; COATED VESICLES; CYTOPLASMIC DOMAIN; INVITRO BINDING; RECEPTOR; SEQUENCE; CLONING; TGN38; MOTIF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Ohno et al., "INTERACTION OF TYROSINE-BASED SORTING SIGNALS WITH CLATHRIN-ASSOCIATED PROTEINS", Science, 269(5232), 1995, pp. 1872-1875

Abstract

Tyrosine-based signals within the cytoplasmic domain of integral membrane proteins mediate clathrin-dependent protein sorting in the endocytic and secretory pathways. A yeast two-hybrid system was used to identify proteins that bind to tyrosine-based signals. The medium chains (mu(1) and mu(2)) of two clathrin-associated protein complexes (AP-1 and AP-2, respectively) specifically interacted with tyrosine-based signals of several integral membrane proteins. The interaction was confirmed by in vitro binding assays. Thus, it is likely that the medium chains serve as signal-binding components of the clathrin-dependent sorting machinery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:30:26