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Titolo:
EFFECT OF L-NMMA, CROMAKALIM, AND GLIBENCLAMIDE ON CEREBRAL BLOOD-FLOW IN HYPERCAPNIA AND HYPOXIA
Autore:
REID JM; DAVIES AG; ASHCROFT FM; PATERSON DJ;
Indirizzi:
UNIV OXFORD,PHYSIOL LAB,PARKS RD OXFORD OX1 3PT ENGLAND UNIV OXFORD,PHYSIOL LAB OXFORD OX1 3PT ENGLAND
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 38, anno: 1995,
pagine: 916 - 922
SICI:
0363-6135(1995)38:3<916:EOLCAG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE POTASSIUM CHANNELS; NITRIC-OXIDE; METHYLENE-BLUE; MUSCLE-CELLS; K+ CHANNELS; ADENOSINE; ARTERIES; RAT; RABBIT; BRAIN;
Keywords:
ADENOSINE; ADENOSINE TRIPHOSPHATE-SENSITIVE POTASSIUM CHANNELS; NITRIC OXIDE; SULFONYLUREAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Reid et al., "EFFECT OF L-NMMA, CROMAKALIM, AND GLIBENCLAMIDE ON CEREBRAL BLOOD-FLOW IN HYPERCAPNIA AND HYPOXIA", American journal of physiology. Heart and circulatory physiology, 38(3), 1995, pp. 916-922

Abstract

Sulfonylureas reduce cerebral blood flow (CBF) during hypoxia but notduring hypercapnia, whereas blockers of nitric oxide (NO) synthesis reduce hypercapnic CBF. However, the effect of NO blockers on hypoxic CBF is uncertain. CBF was measured in the cortex of 51 enflurane-anesthetized rats by the hydrogen clearance technique during eucapnia, hypercapnia (arterial PCO2 65 Torr), and hypoxia (arterial PO2 40 Torr). CBF increased twofold in both hypercapnia and hypoxia from eucapnia. Intracortical (ic) N-G-monomethyl-L-arginine (L-NMMA, 100 mu M-5 mM) attenuated both the hypercapnic and hypoxic dilations by 60-70%, and L-arginine (300 mg/kg iv) partially reversed these effects. Glibenclamide (10 mu M ic) and L-NMMA gave no further attenuation of the hypoxic dilation than L-NMMA alone. Cromakalim (10 mu M, ic) increased CBF in eucapnia, but this was not seen in the presence of glibenclamide. The adenosine antagonist 8-phenyl-theophylline did not attenuate the hypoxic dilation. This suggests that NO synthesis plays a major role in the regulation of CBF in hypercapnia and hypoxia. But the combined effects ofglibenclamide and L-NMMA do not further attenuate CBF in hypoxia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:16:28