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Titolo:
ISCHEMIA-SENSITIVE AND REPERFUSION-SENSITIVE CARDIAC SYMPATHETIC AFFERENTS - INFLUENCE OF H2O2 AND HYDROXYL RADICALS
Autore:
HUANG HS; PAN HL; STAHL GL; LONGHURST JC;
Indirizzi:
UNIV CALIF DAVIS,DEPT INTERNAL MED,DIV CARDIOVASC MED,TB 172 DAVIS CA95616 UNIV CALIF DAVIS,DEPT INTERNAL MED,DIV CARDIOVASC MED DAVIS CA 95616 UNIV CALIF DAVIS,DEPT HUMAN PHYSIOL,DIV CARDIOVASC MED DAVIS CA 95616
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 3, volume: 38, anno: 1995,
pagine: 888 - 901
SICI:
0363-6135(1995)38:3<888:IARCSA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR RECEPTORS; MYOCARDIAL-ISCHEMIA; CORONARY-ARTERY; CARDIOVASCULAR REFLEXES; HYDROGEN-PEROXIDE; VAGAL AFFERENTS; CONSCIOUS DOGS; BRADYKININ; CAT; STIMULATION;
Keywords:
BRADYKININ; CARDIAC DISTENSION; A-DELTA AND C-FIBER AFFERENTS; DIMETHYLTHIOUREA; DEFEROXAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
H.S. Huang et al., "ISCHEMIA-SENSITIVE AND REPERFUSION-SENSITIVE CARDIAC SYMPATHETIC AFFERENTS - INFLUENCE OF H2O2 AND HYDROXYL RADICALS", American journal of physiology. Heart and circulatory physiology, 38(3), 1995, pp. 888-901

Abstract

Activation of cardiac sympathetic affferents leads to excitatory cardiovascular reflexes and pain during myocardial ischemia. We hypothesized that cardiac sympathetic afferents are activated by reactive oxygenspecies produced during ischemia and reperfusion. Single-unit nerve activity of 55 afferents was recorded from the left paravertebral sympathetic chain (T-1-T-4) in cats anesthetized with alpha-chloralose. Receptive fields of all afferents were located on the right or left ventricle. Mechanical and chemical sensitivities of each afferent ending were evaluated by von Frey hairs, cardiac distension, and local application of bradykinin (BK, 142 pmol) or H2O2 (7.5-15 mu mol) to the receptive field. Thirty-one afferents (56%) were responsive to bradykinin (BK), H2O2, and ischemia (2 or 10 min). Deferoxamine (Def, 10-100 mg/kg), dimethylthiourea (DMTU, 10-100 mg/kg), or iron-loaded Def(10 mg/kg) were employed to evaluate the role of H2O2 and hydroxyl radicals (. OH) in activating these afferents (10A delta and 21C fibers) during ischemia and reperfusion. Treatment with the nonspecific scavenger DMTU (n= 10) significantly diminished the increase in discharge activity evoked by ischemia and reperfusion. Treatment with Def also significantlyattenuated the responses during ischemia and reperfusion. Thus reactive oxygen species, particularly . OH, activate a group of cardiac sympathetic A delta- and C-fiber afferents during myocardial ischemia and reperfusion and may play an important role in mediating cardiovascularsympathetic reflex responses and/or pain transmission.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:42:24