Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AURINTRICARBOXYLIC ACID REDUCES PLATELET DEPOSITION IN STENOSED AND ENDOTHELIALLY INJURED RABBIT CAROTID ARTERIES MORE EFFECTIVELY THAN OTHER ANTIPLATELET INTERVENTIONS
Autore:
GOLINO P; RAGNI M; CIRILLO P; PASCUCCI I; EZEKOWITZ MD; PAWASHE A; SCOGNAMIGLIO A; PACE L; GUARINO A; CHIARIELLO M;
Indirizzi:
UNIV NAPLES,SCH MED 2,DEPT INTERNAL MED,DIV CARDIOL,VIA PANSINI 5 I-80131 NAPLES ITALY UNIV NAPLES,SCH MED 2,DIV NUCL MED I-80131 NAPLES ITALY YALE UNIV,DEPT INTERNAL MED,DIV NUCL MED NEW HAVEN CT 00000
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 3, volume: 74, anno: 1995,
pagine: 974 - 979
SICI:
0340-6245(1995)74:3<974:AARPDI>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANINE CORONARY-ARTERIES; CYCLIC FLOW VARIATIONS; RECEPTOR ANTAGONISTS; VONWILLEBRAND-FACTOR; INVIVO MODEL; SHEAR RATE; AGGREGATION; THROMBOSIS; SEROTONIN; THROMBOXANE-A2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
P. Golino et al., "AURINTRICARBOXYLIC ACID REDUCES PLATELET DEPOSITION IN STENOSED AND ENDOTHELIALLY INJURED RABBIT CAROTID ARTERIES MORE EFFECTIVELY THAN OTHER ANTIPLATELET INTERVENTIONS", Thrombosis and haemostasis, 74(3), 1995, pp. 974-979

Abstract

In the present study we tested the effects of different antithrombotic interventions on platelet deposition in experimentally-stenotic rabbit carotid arteries with endothelial injury. Platelet deposition, quantitated by labeling autologous platelets with In-111-oxine, was significantly reduced compared to control animals by all interventions tested, i.e., R 68070, a drug with thromboxane A(2) synthase and receptor blocking properties, BN 52021, a PAF receptor antagonist. aurintricarboxylic acid (ATA), an inhibitor of platelet glycoprotein (Gp) Ib/von Wille-brand factor (VWF) interaction, AZ-1, a monoclonal antibody against rabbit GP IIb/IIIa, the platelet receptor for fibrinogen, and AP-1, a monoclonal antibody against rabbit tissue factor. ATA was significantly more effective than all the other interventions in reducing platelet deposition in the stenotic vessels. We conclude that inhibition of Gp Ib/vWf interaction map be a more suitable target for antithrombotictherapy under conditions of high shear stress, like those produced inthis model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:30:43