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Titolo:
MUCOSAL ULCERATION IN ISOLATED AMPHIBIAN STOMACHS IN-VITRO - ROLES OFNUTRIENT HCO-(3) AND ENDOGENOUS PROSTAGLANDINS
Autore:
TAKEUCHI K; MIYAKE H; OKABE S;
Indirizzi:
KYOTO PHARMACEUT UNIV,DEPT PHARMACOL & EXPTL THERAPEUT KYOTO 607 JAPAN KYOTO PHARMACEUT UNIV,DEPT APPL PHARMACOL KYOTO JAPAN
Titolo Testata:
Digestion
fascicolo: 5, volume: 56, anno: 1995,
pagine: 357 - 363
SICI:
0012-2823(1995)56:5<357:MUIIAS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED GASTRIC-LESIONS; HYPERTONIC NACL; DAMAGE; RATS; CYTOPROTECTION; PROTECTION; MOTILITY; ALCOHOL; HCL;
Keywords:
BULLFROG; GASTRIC SAC; GASTRIC DAMAGE; NUTRIENT HCO-(3); PROSTAGLANDIN; NONSTEROIDAL ANTIINFLAMMATORY; DRUGS(NSAIDS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K. Takeuchi et al., "MUCOSAL ULCERATION IN ISOLATED AMPHIBIAN STOMACHS IN-VITRO - ROLES OFNUTRIENT HCO-(3) AND ENDOGENOUS PROSTAGLANDINS", Digestion, 56(5), 1995, pp. 357-363

Abstract

We examined the effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on mucosal ulceration in isolated bullfrog stomachs and investigated the roles Gastric damage of endogenous prostaglandins (PGs) and nutrient HCO3- in the mucosal protection in vitro. Gastric sacs were prepared by separation from the muscle Prostaglandin layer and incubation for 1-8 h in HCO3- Ringer's solution gassed with 95% O-2/5% CO2 or PO43--Ringer's solution gassed with 100% O-2 in the presence of histamine(1 x 10(-4) M). Under these conditions, multiple ulcers developed in the mucosa only when the gastric sacs were incubated in HCO3--free nutrient solution; both the number and severity of ulcers increased with time and reached a maximum after 6 h of incubation. Luminal pH was decreased because of stimulation of acid secretion by histamine, irrespective of whether the mucosa was bathed in Ringer's solution with or without HCO3-, while gastric potential difference was reduced only in the mucosa bathed in HCO-free nutrient solution. 16,16-Dimethyl PGE(2) added to the nutrient side significantly reduced the number of ulcers developed in the mucosa bathed in HCO3--free nutrient solution. In contrast, indomethacin and aspirin, but not salicylate, caused ulceration even in the mucosa bathed in HCO3--nutrient solution. Histamine-induced acid secretion was reduced by 16,16-dimethyl PGE(2) but not affected by these NSAIDs. In conclusion, ulceration of the isolated gastric mucosa in the presence of acid depends upon either a deficiency of endogenous PGs or a lack of nutrient HCO3-/CO2.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:22:14