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Titolo:
INHIBITION OF ACTH-SECRETION BLOCKS HYPOXIA-INDUCED INCREASE OF ADRENAL-CORTICAL BLOOD-FLOW IN FETAL SHEEP
Autore:
CARTER AM; HOMAN J; FRASER M; RICHARDSON BS; CHALLIS JRG;
Indirizzi:
ODENSE UNIV,DEPT PHYS,WINSLOWPARKEN 19 DK-5000 ODENSE DENMARK UNIV WESTERN ONTARIO,LAWSON RES INST,DEPT PHYSIOL LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,DEPT OBSTET & GYNECOL LONDON ON N6A 4V2 CANADA
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 3, volume: 32, anno: 1995,
pagine: 598 - 604
SICI:
0193-1849(1995)32:3<598:IOABHI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINED HYPOXEMIA; ADRENOCORTICOTROPIC HORMONE; ANESTHETIZED DOGS; RESPONSES; CORTISOL; LAMBS; MICROSPHERES; SENSITIVITY; GESTATION; MEDULLA;
Keywords:
ADRENAL MEDULLARY BLOOD FLOW; CORTICOSTEROIDS; FETAL CIRCULATION; RADIOLABELED MICROSPHERES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Carter et al., "INHIBITION OF ACTH-SECRETION BLOCKS HYPOXIA-INDUCED INCREASE OF ADRENAL-CORTICAL BLOOD-FLOW IN FETAL SHEEP", American journal of physiology: endocrinology and metabolism, 32(3), 1995, pp. 598-604

Abstract

To examine the role of endogenous adrenocorticotropic hormone (ACTH) in adrenal blood flow responses to hypoxia, we studied unanesthetized ovine fetuses during an intravenous infusion of cortisol or vehicle. Fetal hypoxia was induced after 5 h of cortisol or vehicle infusion. Control fetuses were not made hypoxic. Blood flows were determined before and at three time points during the infusions. At 2 and 6 h of hypoxia, in vehicle-infused fetuses, fetal plasma concentrations of immunoreactive ACTH (irACTH) had risen from 9 +/- 3 (SE) pg/ml to 68 +/- 25 and 127 +/- 37 pg/ml, respectively. No significant change in fetal plasma irACTH occurred in the other groups. Adrenal cortical blood flow rose three- to fourfold during hypoxia in vehicle-infused fetuses but did not change from prehypoxia levels in cortisol-infused fetuses (P < 0.005). Medullary flow rose with hypoxemia, and this was not affected by concurrent cortisol infusion. Adrenal blood flows did not change in the control groups. Thus prior infusion of cortisol suppressed the rise in fetal plasma ACTH during hypoxia and selectively blocked the increase in adrenal cortical blood flow.

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Documento generato il 05/04/20 alle ore 00:22:53