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Titolo:
GLUTAMATE STIMULATES INSULIN-SECRETION AND IMPROVES GLUCOSE-TOLERANCEIN RATS
Autore:
BERTRAND G; PUECH R; LOUBATIERESMARIANI MM; BOCKAERT J;
Indirizzi:
CCIPE,CNRS,UPR 9023,RUE CARDONILLE F-34094 MONTPELLIER 5 FRANCE FAC MED MONTPELLIER,INST BIOL,PHARMACOL LAB F-34060 MONTPELLIER 1 FRANCE
Titolo Testata:
American journal of physiology: endocrinology and metabolism
fascicolo: 3, volume: 32, anno: 1995,
pagine: 551 - 556
SICI:
0193-1849(1995)32:3<551:GSIAIG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID RECEPTORS; RELEASE; ANTAGONISTS; MEAL;
Keywords:
GLUTAMATE RECEPTOR; LPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR GLYCEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G. Bertrand et al., "GLUTAMATE STIMULATES INSULIN-SECRETION AND IMPROVES GLUCOSE-TOLERANCEIN RATS", American journal of physiology: endocrinology and metabolism, 32(3), 1995, pp. 551-556

Abstract

We previously showed in vitro that glutamate stimulates insulin release via an lpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor. Here we address a more physiological question concerning the in vivo effect of intravenously or orally administered glutamate on insulinemia and glycemia in fed and fasted rats. In anesthetized fed rats, the intravenous administration of glutamate at 9 and 30 mg/kg transiently increased insulinemia in a dose-dependent manner. The insulin-secretory effect of glutamate (9 mg/kg) was blocked by an antagonist of lpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. In anesthetized fasted rats, glutamate at 9 mg/kg was ineffective, but during an intravenous glucose tolerance test (0.5 g/kg), glutamate markedly potentiated insulin release and increased the glucose disappearance rate. In conscious rats, the intragastric administration of glutamate at 200 mg/kg elicited a transient insulin response in fed animals and had no effect in fasted animals but, during an oral glucose tolerance test (1 g/kg), enhanced insulin secretion and reduced the hyperglycemia. Glutamate was effective at plasma concentrations of 200-300 mu M. In conclusion, intravenously and orally administered glutamate stimulates insulin secretion in vivo via an excitatory amino acid receptor andimproves glucose tolerance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:43:17