Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIURETICS, BETA-BLOCKERS, AND THE RISK FOR SUDDEN CARDIAC DEATH IN HYPERTENSIVE PATIENTS
Autore:
HOES AW; GROBBEE DE; LUBSEN J; TVELD AJMI; VANDERDOES E; HOFMAN A;
Indirizzi:
ERASMUS UNIV ROTTERDAM,SCH MED,DEPT EPIDEMIOL & BIOSTAT,POB 1738 3000DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,SCH MED,DEPT GEN PRACTICE 3000 DR ROTTERDAM NETHERLANDS SOC RECH CARDIOL SA CH-1261 GIVRINS SWITZERLAND ERASMUS UNIV ROTTERDAM,SCH MED,ACAD HOSP DIJKZIGT,DEPT INTERNAL MED 13000 DR ROTTERDAM NETHERLANDS
Titolo Testata:
Annals of internal medicine
fascicolo: 7, volume: 123, anno: 1995,
pagine: 481 -
SICI:
0003-4819(1995)123:7<481:DBATRF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; BLOOD-PRESSURE; ABNORMALITIES; ARRHYTHMIAS; MANAGEMENT; STROKE; MEN;
Keywords:
DEATH, SUDDEN, CARDIAC; HYPERTENSION; ADRENERGIC BETA-ANTAGONISTS; DIURETICS; POTASSIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
A.W. Hoes et al., "DIURETICS, BETA-BLOCKERS, AND THE RISK FOR SUDDEN CARDIAC DEATH IN HYPERTENSIVE PATIENTS", Annals of internal medicine, 123(7), 1995, pp. 481

Abstract

Objective: To determine whether the use of non-potassium-sparing diuretics and beta-blockers is associated with an excess risk for sudden cardiac death in hypertensive patients. Design: Case-control study. Setting: Rotterdam, the Netherlands. Patients: 257 case-patients who had died suddenly while receiving drug therapy for hypertension and 257 living controls also receiving drug therapy for hypertension. Measurements: Detailed information on medication use and clinical characteristics of all case-patients and controls was collected from the files of general practitioners. Additional information on medication use was obtained from computerized pharmacy records. Results: Patients receiving non-potassium-sparing diuretics had an increased risk for sudden cardiac death (relative risk, 1.8 [95% CI, 1.0 to 3.1]) compared with a reference group treated primarily with potassium-sparing diuretics. The corresponding relative risk for beta-blocker use was 1.7 (CI, 1.1 to 2.6). The use of non-potassium-sparing diuretics without beta-blockers was associated with a higher risk for sudden death (relative risk, 2.2 [CI, 1.1 to 4.6]) than was concomitant use of non-potassium-sparing diuretics and beta-blockers (relative risk, 1.4 [CI, 0.6 to 3.0]). The risk for sudden cardiac death among recipients of non-potassium-sparing diuretics was more pronounced in those who had been receiving the diuretic for less than 1 year and in those aged 75 years or younger. Conclusions: The use of non-potassium-sparing diuretics and beta-blockers is associated with an increased risk for sudden cardiac death. This association may offset part of the mortality benefit of these drugs in the treatment of hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:07:48