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Titolo:
ORBITHINE DECARBOXYLASE INHIBITOR ATTENUATES NACL ENHANCEMENT OF GASTRIC CARCINOGENESIS INDUCED BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE
Autore:
TATSUTA M; IISHI H; BABA M; YANO H; UEHARA H; NAKAIZUMI A;
Indirizzi:
CTR ADULT DIS,DEPT GASTROINTESTINAL ONCOL,HIGASHINARI KU,3-3 NAKAMICHI 1 CHOME OSAKA 537 JAPAN
Titolo Testata:
Carcinogenesis
fascicolo: 9, volume: 16, anno: 1995,
pagine: 2107 - 2110
SICI:
0143-3334(1995)16:9<2107:ODIANE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-CHLORIDE; BUTYLATED HYDROXYANISOLE; MONOCLONAL-ANTIBODY; HYPERTONIC NACL; RATS; PROLIFERATION; MUCOSA; CIMETIDINE; CANCER; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
M. Tatsuta et al., "ORBITHINE DECARBOXYLASE INHIBITOR ATTENUATES NACL ENHANCEMENT OF GASTRIC CARCINOGENESIS INDUCED BY N-METHYL-N'-NITRO-N-NITROSOGUANIDINE", Carcinogenesis, 16(9), 1995, pp. 2107-2110

Abstract

The effects of combined administration of NaCl and the ornithine decarboxylase (ODC) inhibitor 1,3-diaminopropane (DAP) on the incidence and number of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and on the ODC activity of the gastric wall and the labeling index of the gastric mucosa were investigated in inbred Wistar rats. Rats were given drinking water with or without 2.5 g/l DAP and chowpellets with and without 10% NaCl ad libitum after 25 weeks of oral administration of MNNG. At week 52 feeding 10% NaCl resulted in significant increases in the incidence of gastric cancers, in the ODC activity of the antral portion of the gastric wall and in the labeling index of antral epithelial cells. Administration of both NaCl and DAP significantly reduced the enhancements by NaCl of gastric carcinogenesis, ODC activity of the antral wall and the labeling index of antral epithelial cells. These results suggest that inhibition of ODC attenuates NaCl enhancement of gastric carcinogenesis and that enhancement by NaCl of gastric carcinogenesis is mediated by polyamine biosynthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 04:44:52