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Titolo:
INHIBITION OF HIV-1 IN-VITRO BY C-5 PROPYNE PHOSPHOROTHIOATE ANTISENSE TO REV
Autore:
LUND OS; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT 144,INFECT DIS LAB DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT 144,INFECT DIS LAB DK-2650 HVIDOVRE DENMARK
Titolo Testata:
Antiviral research
fascicolo: 1, volume: 28, anno: 1995,
pagine: 81 - 91
SICI:
0166-3542(1995)28:1<81:IOHIBC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CHRONICALLY INFECTED-CELLS; GENE-EXPRESSION; OLIGODEOXYNUCLEOTIDES; ANALOGS; OLIGONUCLEOTIDES; SEQUENCE; INVITRO; ELEMENT; AIDS;
Keywords:
HUMAN IMMUNODEFICIENCY VIRUS (HIV); PHOSPHOROTHIOATE; C-5 PROPYNE; ANTISENSE; REV; CHRONIC INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
O.S. Lund et al., "INHIBITION OF HIV-1 IN-VITRO BY C-5 PROPYNE PHOSPHOROTHIOATE ANTISENSE TO REV", Antiviral research, 28(1), 1995, pp. 81-91

Abstract

A 15-mer C-5 propyne modified phosphorothioate oligodeoxynucleotide antisense to rev was approximately 5-fold more effective in providing viral inhibition compared to a 28-mer unmodified phosphorothioate oligodeoxynucleotide targeted to the same sequence and previously shown to inhibit HIV-1 in a sequence-dependent manner. The antiviral effect wasobtained by lipofection or simple addition of 0.2-1 mu M modified oligodeoxynucleotide to the culture medium of H9 cells chronically infected with the HIV-1(LAI) isolate of human immunodeficiency virus type 1. We conclude that C-5 propyne oligodeoxynucleotides in accordance withprevious findings by others are superior to unmodified phosphorothioates in providing inhibition of HIV-1 in a sequence-dependent manner and that this inhibition can be conferred by oligodeoxynucleotides in free solution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:57:47