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Titolo:
HUMAN INTERMEDIATE TROPHOBLASTS EXPRESS CHORIONIC GONADOTROPIN LUTEINIZING HORMONE-RECEPTOR GENE/
Autore:
TAO YX; LEI ZM; HOFMANN GE; RAO CV;
Indirizzi:
UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT OBSTET & GYNECOL,438 MDR BLDG LOUISVILLE KY 40292 UNIV LOUISVILLE,HLTH SCI CTR,SCH MED,DEPT OBSTET & GYNECOL LOUISVILLEKY 40292 BETHESDA CTR REPROD HLTH & FERTIL CINCINNATI OH 00000
Titolo Testata:
Biology of reproduction
fascicolo: 4, volume: 53, anno: 1995,
pagine: 899 - 904
SICI:
0006-3363(1995)53:4<899:HITECG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR PRODUCTION; HUMAN IMPLANTATION TROPHOBLAST; AUTOCRINE PARACRINE FUNCTION; HUMAN-PLACENTA; IMMUNOHISTOCHEMICAL EVIDENCE; HUMAN CYTOTROPHOBLASTS; HUMAN ENDOMETRIAL; GROWTH-FACTOR; DIFFERENTIATION; BIOSYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
Y.X. Tao et al., "HUMAN INTERMEDIATE TROPHOBLASTS EXPRESS CHORIONIC GONADOTROPIN LUTEINIZING HORMONE-RECEPTOR GENE/", Biology of reproduction, 53(4), 1995, pp. 899-904

Abstract

Human cyto- and syncytiotrophoblasts have recently been shown to contain functional hCG/LH receptors. The present study investigated whether human intermediate trophoblasts also contain these receptors. Six implantation sites from 4-8 wk of pregnancy were processed for in situ hybridization for hCG/LH receptors coupled with immunocytochemistry forhuman placental lactogen (hPL), an endocrine marker for intermediate trophoblasts. In addition, the sections were also double-immunostainedfor hCG/LH receptor and hPL proteins. The results showed that some but not all the intermediate trophoblasts contained hCG/LH receptors. The intermediate trophoblasts in endovascular locations contained more receptors than those in perivascular locations. Villus syncytiotrophoblasts contained the highest level of receptors, followed by intermediate trophoblasts in endovascular and perivascular locations and then villus cytotrophoblasts. These data, demonstrating the presence of hCG/LHreceptors in intermediate trophoblasts, suggest a possible role for hCG in trophoblast invasion and maternal recognition of pregnancy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:19:12