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Titolo:
SIGNIFICANCE OF THE C-ERBB FAMILY OF RECEPTOR TYROSINE KINASES IN METASTATIC CANCER AND THEIR POTENTIAL AS TARGETS FOR IMMUNOTHERAPY
Autore:
ECCLES SA; MODJTAHEDI H; BOX G; COURT W; SANDLE J; DEAN CJ;
Indirizzi:
CANC RES INST,IMMUNOL SECT,COTSWOLD RD SUTTON SM2 5NG SURREY ENGLAND
Titolo Testata:
Invasion & metastasis
fascicolo: 1-6, volume: 14, anno: 1994,
pagine: 337 - 348
SICI:
0251-1789(1994)14:1-6<337:SOTCFO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-RECEPTOR; HUMAN GASTRIC-CANCER; HUMAN BREAST-CANCER; TUMOR-CELL GROWTH; MONOCLONAL-ANTIBODY; EGF RECEPTOR; NUDE-MICE; HER-2/NEU EXPRESSION; CARCINOMA INVITRO; URINARY-BLADDER;
Keywords:
TYPE 1 RECEPTOR TYROSINE KINASES; EPIDERMAL GROWTH FACTOR RECEPTOR; C-ERBB2; C-ERBB3; C-ERBB4; MONOCLONAL ANTIBODIES; IMMUNOTHERAPY; BREAST CANCER; METASTASIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Eccles et al., "SIGNIFICANCE OF THE C-ERBB FAMILY OF RECEPTOR TYROSINE KINASES IN METASTATIC CANCER AND THEIR POTENTIAL AS TARGETS FOR IMMUNOTHERAPY", Invasion & metastasis, 14(1-6), 1994, pp. 337-348

Abstract

Overexpression of members of the type 1 receptor tyrosine kinase (c-erbB) family has been documented in many types of cancer. In the case of c-erbB1 (epidermal growth factor receptor) and c-erbB2, this has been closely linked with poor prognosis, and in particular is apparently associated with an invasive/metastatic phenotype and relative insensitivity to conventional therapies. The cell surface location of these molecules renders them attractive targets for a variety of immunotherapeutic strategies, some of which are showing promise in preclinical and early clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:15:34