Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
FIBRINOGEN AND FACTOR-VIII, BUT NOT FACTOR-VII, ARE ASSOCIATED WITH MEASURES OF SUBCLINICAL CARDIOVASCULAR-DISEASE IN THE ELDERLY - RESULTSFROM THE CARDIOVASCULAR HEALTH STUDY
Autore:
TRACY RP; BOVILL EG; YANEZ D; PSATY BM; FRIED LP; HEISS G; LEE M; POLAK JF; SAVAGE PJ;
Indirizzi:
UNIV VERMONT,DEPT PATHOL,AQUATEC BLDG,ROMM T205,55A S PK DR COLCHESTER VT 05446 UNIV VERMONT,DEPT BIOCHEM COLCHESTER VT 05446 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 UNIV WASHINGTON,DEPT MED SEATTLE WA 98195 JOHNS HOPKINS UNIV,DEPT MED BALTIMORE MD 21218 JOHNS HOPKINS UNIV,DEPT EPIDEMIOL BALTIMORE MD 21218 UNIV N CAROLINA,DEPT EPIDEMIOL CHAPEL HILL NC 27599 UNIV CALIF DAVIS,DEPT MED DAVIS CA 95616 BRIGHAM & WOMENS HOSP,DEPT RADIOL BOSTON MA 02115 NHLBI,EPIDEMIOL & BIOMETRY PROGRAM BETHESDA MD 20892 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT HLTH SERV SEATTLE WA 98195
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 9, volume: 15, anno: 1995,
pagine: 1269 - 1279
SICI:
1079-5642(1995)15:9<1269:FAFBNF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA FACTOR-VII; ACUTE CORONARY SYNDROMES; ISCHEMIC-HEART-DISEASE; MYOCARDIAL-INFARCTION; RISK FACTOR; DEGRADATION PRODUCTS; HEMOSTATIC FUNCTION; ARTERIAL-DISEASE; BLOOD-VISCOSITY; ATHEROSCLEROSIS;
Keywords:
CARDIOVASCULAR DISEASE; BLOOD COAGULATION; FACTORS; ELDERLY; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Tracy et al., "FIBRINOGEN AND FACTOR-VIII, BUT NOT FACTOR-VII, ARE ASSOCIATED WITH MEASURES OF SUBCLINICAL CARDIOVASCULAR-DISEASE IN THE ELDERLY - RESULTSFROM THE CARDIOVASCULAR HEALTH STUDY", Arteriosclerosis, thrombosis, and vascular biology, 15(9), 1995, pp. 1269-1279

Abstract

No studies have examined the associations of coagulation factor levels with measures of subclinical cardiovascular disease (CVD) in the elderly. The Cardiovascular Health Study (CHS) is a prospective, population-based cohort study of CVD in persons older than 65 years. At the baseline examination, we measured fibrinogen, factor VII, and factor VIII levels in 5024 of the 5201 participants of the CHS and examined the associations of these coagulation factors with measures of subclinicalCVD in a cross-sectional analysis. Subclinical CVD measures were based on electrocardiography, carotid ultrasonography, echocardiography, and ankle-arm blood pressure measurements (AAI). For analyses, we used the full cohort as well as two mutually exclusive subgroups: those with prevalent clinical CVD at baseline and those without. Fibrinogen andto a lesser extent factor VIII showed positive associations with a variety of subclinical CVD measures. In age-adjusted analyses, fibrinogen and factor VIII were significantly associated with 8 of 10 measures. In multivariate analyses, and AAI. Factor VIII was associated with abnormal wall motion and AAI in the full cohort only. Factor VII was notconsistently associated with subclinical disease measures. In bivariate analyses that included data from all three groups, there were 5 positive subclinical disease associations and 5 negative associations forfactor VII. In multivariate analyses, there were no significant associations between factor VII and subclinical CVD in the full cohort or in either subgroup. We conclude that in these cross-sectional analyses,fibrinogen and to a lesser extent factor VIII are associated with subclinical CVD in the elderly, even in those without symptoms or a history of clinical CVD. Factor VII, however, was not associated with subclinical CVD in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:17:04