Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANALYSIS OF THE ENANTIOMERS OF 3,4-METHYLENEDIOXY-N-ETHYLAMPHETAMINE (MDE, EVE) AND ITS METABOLITE 3,4-METHYLENEDIOXYAMPHETAMINE (MDA) IN RAT-BRAIN
Autore:
HEGADOREN KM; BAKER GB; COUTTS RT;
Indirizzi:
UNIV ALBERTA,DEPT PSYCHIAT,NEUROCHEM RES UNIT EDMONTON AB T6G 2B7 CANADA UNIV ALBERTA,DEPT PSYCHIAT,NEUROCHEM RES UNIT EDMONTON AB T6G 2B7 CANADA UNIV ALBERTA,FAC PHARM PHARMACEUT SCI EDMONTON AB T6G 2B7 CANADA
Titolo Testata:
Journal of pharmacological and toxicological methods
fascicolo: 2, volume: 34, anno: 1995,
pagine: 117 - 123
SICI:
1056-8719(1995)34:2<117:AOTEO3>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPAMINERGIC SYSTEMS; MDMA ECSTASY; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; METHYLENEDIOXYMETHAMPHETAMINE; INVITRO; INVIVO; 3,4-(METHYLENEDIOXY)METHAMPHETAMINE; 2,4,5-TRIHYDROXYMETHAMPHETAMINE; CHROMATOGRAPHY; IDENTIFICATION;
Keywords:
CHIRALITY; METHYLENEDIOXY ANALOGS OF AMPHETAMINE; GAS-LIQUID CHROMATOGRAPHY; METABOLIC N-DEALKYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Hegadoren et al., "ANALYSIS OF THE ENANTIOMERS OF 3,4-METHYLENEDIOXY-N-ETHYLAMPHETAMINE (MDE, EVE) AND ITS METABOLITE 3,4-METHYLENEDIOXYAMPHETAMINE (MDA) IN RAT-BRAIN", Journal of pharmacological and toxicological methods, 34(2), 1995, pp. 117-123

Abstract

The methylenedioxy analogues of amphetamine are used recreationally despite concerns raised regarding potential neurotoxicity of the parentcompounds and a number of metabolites. Much has been written regarding 3,4-methylenedioxymethamphetamine (MDMA; ''Ecstasy''), but there is less information available on 3,4-methylenedioxy-N-ethylamphetamine (MDE; ''Eve''), despite recent reports indicating the abuse of this drugand its potentially serious side effects. An assay procedure was developed for the simultaneous quantitation of both enantiomers of MDE andits metabolite MDA; the method involves derivatization with an optically pure reagent and analysis on a gas chromatograph equipped with a capillary column and a nitrogen-phosphorus detector. Brain levels of the enantiomers of MDE and MDA were examined in the rat at different time periods after acute i.p. injections of racemic MDE and the results were compared with levels of MDMA and MDA obtained after i.p. injectionof MDMA in a previous study from our laboratories. The levels of the enantiomers of MDE and MBA achieved at 1, 4, and 8 hr were lower than in the case of MDMA. Stereoselective differences in brain levels of enantiomers of the parent drug and metabolite were much less marked withMDE than with MDMA, but where these small differences did exist in the case of MDE, the (R)-(-) vs (S)-(+) relationship was opposite to that reported for MDMA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 12:08:58