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Titolo:
ELEVATED IL-8 PRODUCTION BY TRAUMA PATIENTS MONOCYTES IS ASSOCIATED WITH ELEVATED SECRETION OF TNF-ALPHA
Autore:
DE AK; KODYS K; PUYANA JC; FUDEM G; SAVOIE P; MILLERGRAZIANO CL;
Indirizzi:
UNIV MASSACHUSETTS,MED CTR,DEPT SURG,55 LAKE AVE N WORCESTER MA 01655 UNIV MASSACHUSETTS,MED CTR,DEPT SURG WORCESTER MA 01655 UNIV MASSACHUSETTS,MED CTR,DEPT MOLEC GENET & MICROBIOL WORCESTER MA 01655
Titolo Testata:
Shock
fascicolo: 3, volume: 4, anno: 1995,
pagine: 171 - 177
SICI:
1073-2322(1995)4:3<171:EIPBTP>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SEPTIC SHOCK; PROSTAGLANDIN-E2 PRODUCTION; INFLAMMATORY MEDIATORS; INTERLEUKIN-6 IL-6; THERMAL-INJURY; CYTOKINE; SEPSIS; LIPOPOLYSACCHARIDE; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A.K. De et al., "ELEVATED IL-8 PRODUCTION BY TRAUMA PATIENTS MONOCYTES IS ASSOCIATED WITH ELEVATED SECRETION OF TNF-ALPHA", Shock, 4(3), 1995, pp. 171-177

Abstract

IL-8 is a recently described chemokine that increases polymorphonuclear neutrophil infiltration and has been implicated in inflammatory pathology. This study assesses monocyte (MO) interleukin-8 (IL-8) levels in severe trauma patients (injury severity score > 16) who have elevated levels of MO cell-associated tumor necrosis factor alpha (TNF alpha), a major marker for systemic inflammatory response syndrome after injury. We demonstrate elevated (p = .0007) levels of MO IL-8 only in those trauma patients who also have increased (p = .0001) MO-secreted TNF alpha whereas the patients having normal MO-secreted TNF alpha levels have normal or even decreased MO IL-8 production. There is no association between MO IL-8 production and cell-associated TNF alpha levels. MO induction by Fc gamma RI cross-linking, a common induction pathwayin trauma patients' MO that increases the production of both cell-associated and secreted TNF alpha, can also increase (p = .0022) MO IL-8 levels. Therefore, post-trauma elevation of MO IL-8 levels may be associated with increased secreted TNF alpha resulting from, at least in part, Fc gamma RI cross-linking stimulation in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:03:11