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Titolo:
HGF SF - A POTENT CYTOKINE FOR MAMMARY GROWTH, MORPHOGENESIS AND DEVELOPMENT/
Autore:
NIRANJAN B; BULUWELA L; YANT J; PERUSINGHE N; ATHERTON A; PHIPPARD D; DALE T; GUSTERSON B; KAMALATI T;
Indirizzi:
INST CANC RES,DIV CELL BIOL & EXPLT PATHOL,15 COTSWALD RD SUTTON SM2 5NG SURREY ENGLAND CHARING CROSS & WESTMINSTER MED SCH,DEPT BIOCHEM & MED ONCOL LONDON W6 8RF ENGLAND
Titolo Testata:
Development
fascicolo: 9, volume: 121, anno: 1995,
pagine: 2897 - 2908
SICI:
0950-1991(1995)121:9<2897:HS-APC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR SCATTER FACTOR; TYROSINE KINASE; EXTRACELLULAR-MATRIX; MYOEPITHELIAL CELLS; BASAL LAMINA; HUMAN-BREAST; RAT CASEIN; GLAND; EXPRESSION; DIFFERENTIATION;
Keywords:
HGF/SF; C-MET; LUMINAL CELL; MYOEPITHELIAL CELL; MAMMARY FIBROBLAST; GROWTH AND MORPHOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
75
Recensione:
Indirizzi per estratti:
Citazione:
B. Niranjan et al., "HGF SF - A POTENT CYTOKINE FOR MAMMARY GROWTH, MORPHOGENESIS AND DEVELOPMENT/", Development, 121(9), 1995, pp. 2897-2908

Abstract

The mammary gland is a renewing tissue in which morphogenetic processes and differentiation occur cyclically during the menstrual cycle, pregnancy and lactation, These events have been shown to be dependent upon epithelial-mesenchymal interactions. Studies of the effects of individual factors, their cellular source and their target cell populations in the different developmental stages of the mammary gland are greatly facilitated by the accessibility of this organ and the application of new techniques that allow purification of the major epithelial and stromal components of this tissue. Here we demonstrate that HGF/SF andits cellular receptor, c-met, are expressed and regulated temporally during mouse mammary development and differentiation. We show that human and mouse mammary fibroblasts produce HGF/SF and that HGF/SF is notonly mitogenic but morphogenic and motogenic for both human and mousemammary epithelial cells, We have found that human luminal and myoepithelial cells express c-met differentially and that HGF/SF has different effects on these two mammary epithelial cell populations, HGF/SF ismitogenic for luminal cells but not myoepithelial cells, and morphogenic to myoepithelial cells but not luminal cells, This is discussed inthe context of the proliferative compartments in the normal mammary gland and the potential role of the myoepithelial cells to act as the skeleton for ductal development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:04:33