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Titolo:
THE ROLE OF IMMUNOSUPPRESSION IN THE EFFICACY OF CANCER GENE-THERAPY USING ADENOVIRUS TRANSFER OF THE HERPES-SIMPLEX THYMIDINE KINASE GENE
Autore:
ELSHAMI AA; KUCHARCZUK JC; STERMAN DH; SMYTHE WR; HWANG HC; AMIN KM; LITZKY LA; ALBELDA SM; KAISER LR;
Indirizzi:
HOSP UNIV PENN,DEPT SURG,GEN THORAC SURG SECT,4 SILVERSTEIN BLDG,3400SPRUCE ST PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED,PULM CRIT CARE SECT PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT SURG,THORAC SURG SECT PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT PATHOL PHILADELPHIA PA 19104 UNIV PENN,MED CTR,THORAC ONCOL RES LAB PHILADELPHIA PA 19104
Titolo Testata:
Annals of surgery
fascicolo: 3, volume: 222, anno: 1995,
pagine: 298 - 310
SICI:
0003-4932(1995)222:3<298:TROIIT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN-TUMORS; RATS; REGRESSION; VECTORS; PATHOGENESIS; EXPRESSION; PNEUMONIA; CELLS; LIVER; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Elshami et al., "THE ROLE OF IMMUNOSUPPRESSION IN THE EFFICACY OF CANCER GENE-THERAPY USING ADENOVIRUS TRANSFER OF THE HERPES-SIMPLEX THYMIDINE KINASE GENE", Annals of surgery, 222(3), 1995, pp. 298-310

Abstract

Objective To determine whether the immune system limits or improves the therapeutic efficacy of an adenovirus vector expressing the herpes simplex thymidine kinase (HSVtk) gene in a subcutaneous tumor model. Background Data Enhanced immune reactions against tumors may be therapeutically useful. However, recent studies with adenoviral vectors show that immune responses limit the efficacy and persistence of gene expression. The effect of the immune response on cancer gene therapy with HSVtk gene delivery by an adenovirus vector followed by treatment with ganciclovir is unclear. Methods After adenoviral transduction of a Fischer rat syngeneic mesothelioma cell line with the HSVtk gene in vitro, subcutaneous flank tumors were established. The ability of the HSVtk/ganciclovir system to inhibit tumor growth was compared among normal Fischer rats, immunodeficient nude rats, and Fischer rats immunosuppressed with cyclosporin. Results HSVtk/ganciclovir therapy was more effective in nude rats and immunosuppressed Fischer rats than in immunocompetent Fischer rats. Conclusion These results indicate that the immuneresponse against adenovirally transduced cells limits the efficacy ofthe HSVtk/ganciclovir system and that immunosuppression appears to bea useful adjunct. These findings have important implications for clinical trials using currently available adenovirus vectors as well as for future vector design.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:55:00