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Titolo:
EFFECT OF BQ123 ON VASOCONSTRICTION AS A RESULT OF EITHER HYPOXIA OR ENDOTHELIN-1 IN PERFUSED RAT LUNGS
Autore:
TAKEOKA M; ISHIZAKI T; SAKAI A; CHANG SW; SHIGEMORI K; HIGASHI T; UEDA G;
Indirizzi:
SHINSHU UNIV,SCH MED,AGING & ADAPTAT RES CTR MATSUMOTO NAGANO 390 JAPAN FUKUI MED SCH,DEPT INTERNAL MED 3 FUKUI 91011 JAPAN NORTHWESTERN UNIV,SCH MED,PULM SECT CHICAGO IL 00000
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 155, anno: 1995,
pagine: 53 - 60
SICI:
0001-6772(1995)155:1<53:EOBOVA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY VASOCONSTRICTION; INTRAPULMONARY ARTERIES; RECEPTOR SUBTYPES; ETA RECEPTOR; EDEMA; CIRCULATION; OCCLUSION; INCREASES; PRESSURE; BQ-123;
Keywords:
LUNG WEIGHT; PULMONARY ARTERIAL RESISTANCE; PULMONARY MICROVASCULAR PRESSURE; PULMONARY VENOUS RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Takeoka et al., "EFFECT OF BQ123 ON VASOCONSTRICTION AS A RESULT OF EITHER HYPOXIA OR ENDOTHELIN-1 IN PERFUSED RAT LUNGS", Acta Physiologica Scandinavica, 155(1), 1995, pp. 53-60

Abstract

A possible role of endothelin (ET)-1 in mediating hypoxic pulmonary vasoconstriction (HPV) was examined by comparing haemodynamic differences between ET-l-induced vasoconstriction and HPV in isolated perfused rat lungs. An ET(A) receptor antagonist (BQ123) was also employed to assess the effects of ET-1. The pulmonary arterial pressure (Ppa) was significantly increased by alveolar hypoxia (3% O-2) and by ET-1 (5 nM). The pulmonary microvascular pressure was not changed by hypoxia, butincreased more than two-fold by ET-1 (P < 0.01), Hypoxia significantly increased pulmonary arterial resistance (P < 0.01) while ET-1 significantly increased pulmonary venous resistance (P < 0.01), and slightlyincreased arterial resistance. Lung weight was increased by ET-1 and decreased by hypoxia, accompanied by similar Ppa responses in both cases. BQl23 (10(-6) M and 10(-5) M) did not influence the changes in Ppaand lung weight induced by hypoxia or angiotensin II (0.3 mu g). BQ123 did, however, suppress (P < 0.05) the increase in Ppa and lung weight induced by 5 nM ET-1. Thus, it appears unlikely that ET-1 is involved in changes in pulmonary vascular tone during acute HPV.

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Documento generato il 04/12/20 alle ore 18:49:29